Bromelain Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 9001-00-7 |
| Product name | Bromelain |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeFood GradeCosmetic Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Bromelain
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Bromelain Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Bromelain
| Industry | Application | Process |
|---|---|---|
| Food Industry | Meat tenderizer | Spray or soak raw meat surface with bromelain solution and incubate at 4–10 °C for 30–120 minutes to hydrolyze myofibrillar proteins and collagen, thereby improving tenderness |
| Food Industry | Beer clarifying agent | Add 0.05–0.2 g/L bromelain during cold storage (0–4 °C) to hydrolyze residual haze-forming proteins (e.g., LTP1) and prevent chill haze formation |
| Food Industry | Baking improver | Add at 0.001–0.01% (w/w) during dough mixing to moderately hydrolyze gluten proteins, reducing dough elasticity while enhancing extensibility and gas retention |
| Pharmaceutical Industry | Adjunctive anti-inflammatory and anti-edema agent | Formulated into oral tablets or topical gels at 50–200 FIP-U/g to exert anti-inflammatory effects by inhibiting bradykinin, prostaglandin, and leukotriene production |
| Pharmaceutical Industry | Debridement enzyme formulation component | Combined with streptokinase, urokinase, etc., into topical debridement gels (pH 6.0–7.5) to selectively hydrolyze fibrin and denatured proteins in necrotic tissue while preserving viable tissue |
| Cosmetics Industry | Keratin conditioning agent | Added at 0.005–0.02% (w/w) in exfoliating creams or masks to gently hydrolyze abnormal keratin in the stratum corneum under pH 5.5–6.5 conditions, promoting epidermal renewal |
| Biotechnology | Proteolytic tool enzyme for protein structure studies | Cleaves peptide bonds C-terminal to arginine and lysine residues specifically in Tris-HCl buffer (pH 7.0–8.0, 25 °C), used for protein sequencing and peptide mapping |
Manufacturing Quality Control of Bromelain
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Enzyme Activity | UV Spectrophotometry (e.g., Folin-Phenol Method) | Casein or other protein substrates are hydrolyzed by bromelain under specific pH and temperature conditions, producing soluble peptides. These peptides react with Folin-phenol reagent, and absorbance is measured at 660 nm to calculate enzyme activity units (U/mg). |
| Protein Content | BCA Assay or Lowry Method | Based on the reaction between proteins and copper ions to form complexes, which further react with BCA reagent to produce a purple compound. Absorbance is measured at 562 nm, and total protein concentration is determined using a standard curve. |
| Appearance and Characteristics | Visual Inspection | Observe color, physical state (e.g., light yellow to brownish-yellow powder), odor, and whether caking occurs, to assess compliance with physical specifications. |
| Moisture Content | Karl Fischer Titration or Loss on Drying | Karl Fischer method provides precise moisture determination; loss on drying involves drying the sample at 105°C to constant weight, with moisture content calculated from the weight loss. |
| pH Value | pH Meter Measurement | Dissolve bromelain in water to a defined concentration (e.g., 1%) and measure pH using a calibrated pH meter. The typical pH range is 4.5–6.0. |
| Microbial Limits | Plate Count Method, Membrane Filtration | Determine total aerobic microbial count, mold and yeast count, and test for specified microorganisms (e.g., *E. coli*, *Salmonella*) to ensure compliance with pharmacopoeial or food safety standards. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine residual levels of heavy metals such as lead, arsenic, mercury, and cadmium to ensure compliance with food safety or pharmaceutical standards (e.g., Chinese Pharmacopoeia, USP). |
| Specific Activity | Calculated from Enzyme Activity / Protein Content | Divide the measured enzyme activity (in units) by the total protein content to obtain specific activity (U/mg protein), used to evaluate enzyme purity and catalytic efficiency. |
| Particle Size Distribution | Laser Diffraction Analysis | Use a laser particle size analyzer to determine the particle size distribution of the powder, ensuring good solubility and stability. |
| Impurities and Residual Solvents | Gas Chromatography (GC) | Detect organic solvents (e.g., ethanol, acetone) that may remain from manufacturing processes, ensuring compliance with ICH or pharmacopoeial guidelines for residual solvents. |
Technical Specifications of Bromelain
| Test Item | Specification |
|---|---|
| Appearance | White to light tan lyophilized powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=1.0% |
| Odor | Characteristic mild enzymatic odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Bromelain
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of Bromelain
Industrial Bromelain Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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