Ethyl (R)-2-hydroxy-4-phenylbutyrate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 90315-82-5 |
| Product name | Ethyl (R)-2-hydroxy-4-phenylbutyrate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ethyl (R)-2-hydroxy-4-phenylbutyrate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ethyl (R)-2-hydroxy-4-phenylbutyrate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ethyl (R)-2-hydroxy-4-phenylbutyrate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for the synthesis of the antihypertensive drug benazepril | Chiral resolution or asymmetric hydrogenation to synthesize the key side chain of benazepril |
| Pharmaceuticals | Chiral intermediate for the synthesis of the antihypertensive drug trandolapril | Construction of the S-configured monoester side chain of trandolapril via hydrolysis, amidation, and related steps |
| Pharmaceuticals | Chiral building block for preparing other ACE inhibitor drugs | Used as an (R)-configured hydroxy acid ester precursor; peptide bond structures are introduced via selective protection and functional group transformations |
Manufacturing Quality Control of Ethyl (R)-2-hydroxy-4-phenylbutyrate
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) Proton Nuclear Magnetic Resonance (¹H NMR) |
Confirm the compound structure as (R)-2-hydroxy-4-phenylbutyric acid ethyl ester by characteristic absorption peaks in IR spectra or specific chemical shifts and coupling constants in ¹H NMR spectra. |
| Optical Purity / Enantiomeric Excess (e.e.) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) Chiral Gas Chromatography (Chiral GC) |
Separate enantiomers using chiral stationary phase columns; calculate the content of the (R)-enantiomer based on peak areas to assess optical purity, typically requiring e.e. ≥98%. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) Gas Chromatography (GC) |
Quantify the main component using external or internal standard methods via reversed-phase HPLC or GC, ensuring product purity meets specification (e.g., ≥98.0%). |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic elution programs to separate and detect potential process impurities and degradation products. Individual impurities are generally controlled at ≤0.5%, with total impurities ≤1.0%. |
| Water Content | Karl Fischer Titration | Determine water content quantitatively through reaction with Karl Fischer reagent; typically requires ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC, Headspace Sampling) | Test for residual organic solvents (e.g., ethanol, toluene, dichloromethane) from manufacturing processes according to ICH Q3C guidelines using headspace-GC, ensuring compliance with specified limits. |
| Melting Point | Capillary Melting Point Method | Determine the melting temperature range as a physical constant for auxiliary identification and purity assessment (applicable if solid; may be omitted if the material is oily in certain batches). |
| Specific Rotation | Polarimeter Method | Measure the optical rotation of the sample solution under specified wavelength (typically sodium D line, 589 nm) and temperature, then calculate specific rotation to verify stereochemical configuration and consistency of optical purity. |
Technical Specifications of Ethyl (R)-2-hydroxy-4-phenylbutyrate
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=99.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -8.0 to -11.0 deg (c=1, in CHCl3) |
| Refractive Index (n20/D) | 1.515–1.525 |
| Relative Density (20°C/25°C) | 1.060–1.075 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ethyl (R)-2-hydroxy-4-phenylbutyrate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Ethyl (R)-2-hydroxy-4-phenylbutyrate
Safety Information of Ethyl (R)-2-hydroxy-4-phenylbutyrate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Ethyl (R)-2-hydroxy-4-phenylbutyrate
Industrial Ethyl (R)-2-hydroxy-4-phenylbutyrate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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