Hydroxypropyl methylcellulose phthalate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 9050-31-1 |
| Product name | Hydroxypropyl methylcellulose phthalate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeFood GradeCosmetic Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Hydroxypropyl methylcellulose phthalate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Hydroxypropyl methylcellulose phthalate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Hydroxypropyl methylcellulose phthalate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Enteric coating material | Applied as an enteric coating for solid dosage forms (e.g., tablets, capsules) to prevent drug degradation in the acidic gastric environment and ensure release in the intestine |
| Pharmaceuticals | Excipient for sustained-release formulations | Used as a film-forming agent in sustained- or controlled-release formulations to modulate drug release rate |
| Food (in certain countries/regions) | Food additive (coating agent) | Applied as a surface coating for confectionery and dietary supplements to impart gloss and provide protection (subject to local regulatory compliance) |
| Cosmetics | Film former/stabilizer | Used in nail polish, hair sprays, and similar products to form films or stabilize formulation systems (usage subject to regional regulatory restrictions) |
Manufacturing Quality Control of Hydroxypropyl methylcellulose phthalate
| Test Item | Common Test Method | Method Summary |
|---|---|---|
| Appearance | Visual Inspection | Examine the sample under natural light for color, physical state, and presence of caking. Should be white to off-white powder, free from foreign matter. |
| Identification | Infrared Spectroscopy (IR) | Compare the sample spectrum with a reference standard, confirming characteristic absorption peaks (e.g., C=O stretching vibration around 1720 cm⁻¹, C-O, etc.) to verify molecular structure. |
| Chemical Color Reaction | Utilize the characteristics of phthalate esters; add specific reagents (e.g., hydrolyze with sodium hydroxide, then acidify to precipitate or produce coloration). | |
| Viscosity | Rotational Viscometer / Ubbelohde Viscometer | Prepare a solution of specified concentration (e.g., 2%) in water (usually dissolved under alkaline conditions), and measure dynamic viscosity at a defined temperature (e.g., 20°C) to reflect polymer molecular weight. |
| Acid Value / Free Acid Content | Acid-Base Titration | Dissolve the sample in a suitable solvent (e.g., ethanol-water mixture), titrate with standard NaOH solution, and calculate mg of KOH consumed per gram of sample (mg KOH/g), indicating the degree of esterification and stability. |
| Methoxy Content | Gas Chromatography (GC) or Gravimetric Method | Sample is cleaved with strong acid to produce methyl iodide, which is detected by GC or measured via absorption and weighing; used to control degree of substitution. |
| Hydroxypropoxy Content | Gas Chromatography (GC) | Sample is cleaved with hydrochloric acid to generate propyl iodide, and the content is determined by GC to assess the extent of hydroxypropyl substitution. |
| pH Value | pH Meter Measurement | Prepare a dispersion of defined concentration (e.g., 1%) in water, and measure pH using a calibrated pH meter. Typically slightly acidic. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | Dry the sample at a specified temperature (e.g., 105°C) to constant weight, and calculate the percentage weight loss to control moisture and volatile content. |
| Sulfated Ash (Residue on Ignition) | Gravimetric Method (High-Temperature Ignition) | Iignite the sample in a muffle furnace at 500–600°C to constant weight, then weigh the residue to determine inorganic impurity content. |
| Heavy Metals | Thioacetamide Method (as per Chinese Pharmacopoeia) | After sample digestion, react with thioacetamide under acidic conditions to form colored sulfides; measure total heavy metals (e.g., lead) by colorimetry. |
| Microbial Limits | Microbiological Culture Method | Perform tests according to the Chinese Pharmacopoeia or USP requirements, including total aerobic microbial count, mold and yeast count, and specified microbial tests. |
| Solubility and Enteric Performance | Dissolution Test (Simulated Gastric and Intestinal Fluids) | No disintegration in pH 1.2 hydrochloric acid solution for 2 hours; complete disintegration and release within 1 hour in pH 6.8 phosphate buffer, verifying enteric coating properties. |
| Degree of Substitution (DS) | Elemental Analysis or Nuclear Magnetic Resonance (NMR) | Determine the ratio of OCH₃ and OCH₂CHOHCH₂OH groups via elemental analysis, or use ¹³C NMR for precise determination of substitution sites and extent. |
Technical Specifications of Hydroxypropyl methylcellulose phthalate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.3% |
| Residue on Ignition | <=1.0% |
| Heavy Metals | <=20 ppm |
| Acid Value (mg KOH/g) | 15.0 - 25.0 mg KOH/g |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Hydroxypropyl methylcellulose phthalate
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Packaging of Hydroxypropyl methylcellulose phthalate
Industrial Hydroxypropyl methylcellulose phthalate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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