tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 907544-17-6 |
| Product name | tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Serves as a key intermediate in the synthesis of bioactive molecules, including drug candidates | Constructs piperidine ring structures in chiral synthesis; the amine group is BOC-protected, and both the fluorine atom and amine group are available for further derivatization |
| Drug Discovery | Used to synthesize receptor antagonists or enzyme inhibitors, particularly for neurological disorders and oncology | Serves as a building block in multistep syntheses, participating in reactions such as amide bond formation and nucleophilic substitution |
| Academic Research | Employed as a tool molecule or reference compound for methodology development and mechanistic studies | Applied in asymmetric synthesis, fluorine chemistry research, and pharmacological screening assays |
Manufacturing Quality Control of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210-220 nm, comparing peak area to calibrated standard. |
| Chiral Purity | Chiral HPLC | Separates enantiomers on a chiral stationary phase and quantifies (3R,4S) isomer relative to diastereomeric impurities. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., THF, EtOAc, MeOH) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Measures trace water via coulometric or volumetric titration based on iodine-sulfur dioxide redox reaction in pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Fe) after acid digestion using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-MS | Specific quantification of Pd from catalytic hydrogenation steps using high-sensitivity ICP-MS after microwave digestion. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related degradants and synthesis intermediates by gradient reverse-phase HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using controlled heating and optical observation. |
| Optical Rotation | [alpha]D Measurement | Measures specific rotation at 589 nm using sodium D-line light to confirm chiral integrity and concentration. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or dispersed particle size distribution based on angular scattering intensity of laser light. |
| Loss on Drying | Gravimetric Thermobalance | Determines volatile content by measuring mass loss after controlled heating under nitrogen or vacuum. |
Technical Specifications of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Optical Rotation | +28.0 to +32.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
Safety Information of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
Industrial tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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