(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 915095-94-2 |
| Product name | (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing antithyroid agents or metabolic modulators | Synthesized via Suzuki coupling, nucleophilic substitution, and cyclization, starting from (3S)-tetrahydrofuranol and proceeding through phenoxylation, benzylation, and halogenated aryl coupling steps |
Manufacturing Quality Control of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
| Test Item | Common Test Methods | Method Summary |
|---|---|---|
| Appearance and Physical Form | Visual inspection, Melting point determination | Observe sample as white to off-white crystalline powder; determine melting range (typically within ±2°C of literature value) to preliminarily assess purity and crystal form consistency. |
| Identification Tests | High-Performance Liquid Chromatography (HPLC), Infrared Spectroscopy (IR), Nuclear Magnetic Resonance Spectroscopy (¹H/¹³C NMR) | HPLC comparison with reference standard retention time; IR matching of characteristic peaks (e.g., C–Cl, C–I, ether bond C–O–C); NMR analysis of aromatic protons, tetrahydrofuran ring protons, and chemical shifts near chiral centers to confirm molecular structure. |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography (HPLC-DAD/UV) | Use C18 column with gradient elution (water-acetonitrile or methanol), UV detection at 210–280 nm; quantitatively control known impurities (e.g., dechlorinated/deiodinated by-products, hydrolysis products, stereoisomers), typically limited to ≤0.5%–1.0%. |
| Residual Solvents | Gas Chromatography (GC-FID) | In accordance with ICH Q3C, detect common organic solvents such as ethanol, acetone, dichloromethane, and acetonitrile; use headspace or direct injection with polar column (e.g., DB-WAX) for separation and quantification. |
| Water Content | Karl Fischer Titration | Precisely measure trace moisture in the sample; limit to ≤0.5% (depending on dosage form requirements) to prevent hydrolysis or stability issues. |
| Assay (Active Ingredient) | High-Performance Liquid Chromatography (HPLC-UV) | Use a validated HPLC method with external or internal standardization for quantification; detection wavelength typically at 254 nm (due to iodophenyl absorption); linear range 0.05–2.0 mg/mL, R² ≥ 0.999, recovery rate 98–102%. |
| Chiral Purity (Enantiomeric Impurities) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use chiral stationary phase columns (e.g., Chiralpak AD-H, OD-H, or Chiralcel OB-H), mobile phase of n-hexane/isopropanol or ethanol; detect content of (3R) isomer and limit to ≤0.1%. |
| Heavy Metals and Elemental Impurities | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detect lead, cadmium, mercury, arsenic, and residual iodides (due to iodine content); comply with ICH Q3D guidelines, especially monitoring non-target forms of iodine. |
| UV Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Determine maximum absorption wavelength (λmax ≈ 250–260 nm, contributed by iodophenyl group) in ethanol or methanol; used for auxiliary identification and solution stability evaluation. |
| Solubility | Shake-flask method / Visual observation | Determine solubility in water, ethanol, DMSO, ethyl acetate, etc., supporting formulation development and analytical method design (e.g., HPLC solvent selection). |
| Stability-Indicating Test | Forced Degradation HPLC Method | Subject sample to acidic, basic, oxidative, thermal, and photolytic stress conditions; monitor degradation products via HPLC to verify method specificity and compound stability. |
Technical Specifications of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Optical Rotation | +4.5 to +5.5° (c=1, in chloroform) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Safety Information of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Industrial (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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