tert-Butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 916420-27-4 |
| Product name | tert-Butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 916420-27-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 916420-27-4 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 916420-27-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate for JAK2 kinase inhibitors | Used in structural modification and functional group introduction steps for synthesizing JAK inhibitors such as ruxolitinib, involving multi-step reactions including deprotection, chlorination, and amination to construct the core pyrimido[2,1-f]pyrimidine scaffold |
Manufacturing Quality Control of 916420-27-4
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare it with reference spectra to confirm functional groups and molecular structural characteristics. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze chemical shifts, coupling constants, and other properties of hydrogen atoms using NMR technology to verify consistency of molecular structure. | |
| Mass Spectrometry (MS) | Detect molecular ion peaks and fragment ions to confirm molecular weight and structural fragments; often coupled with liquid chromatography (LC-MS). | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase column and UV detector (e.g., 254 nm) to quantify the main component; calculate concentration using external standard or area normalization method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Using the same conditions as assay or gradient elution, separate and quantify process impurities, degradation products, etc.; typically with specified acceptance criteria for impurities. |
| Residual Solvents | Gas Chromatography (GC), Headspace Injection | Detect organic solvents possibly remaining from synthesis (e.g., dichloromethane, methanol, acetonitrile) in accordance with ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Determine water content using volumetric or coulometric methods; suitable for moisture-sensitive organic compounds. |
| Melting Point | Melting Point Apparatus | Measure the melting temperature range of the compound; used as a physical constant for preliminary identification and purity assessment. |
| Appearance and Characteristics | Visual Inspection | Observe physical properties such as color, crystal form, odor, etc.; should conform to standard descriptions (e.g., white to off-white crystalline powder). |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) |
Detect residual catalysts (e.g., Pd, Cu) or other heavy metal impurities, meeting pharmacopoeial or ICH Q3D requirements. |
| pH (if applicable) | pH Meter (in solution) | Prepare a solution of the sample at a defined concentration in water or buffer, then measure pH to evaluate the impact of acidity or alkalinity on stability. |
Technical Specifications of 916420-27-4
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 916420-27-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 916420-27-4
Industrial 916420-27-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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