China Factory Direct
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| CAS number | 917389-26-5 |
| Product name | 2-Propenoic acid, 3-[3-fluoro-2-[[[[2-methoxy-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-, methyl ester, (2E)- |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for anticancer drugs | Used in organic synthesis |
| Pharmaceuticals | Intermediate for tyrosine kinase inhibitors | Used in chemical synthesis |
| Research | Raw material for drug development | Prepared in laboratory settings |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 220-254 nm, comparing peak area to calibrated standard. |
| Related Substances | HPLC-UV | Detects and quantifies impurities (e.g., isomers, degradants, synthesis intermediates) via gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, acetone, toluene) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration based on iodine-sulfur dioxide reaction in pyridine/methanol medium. |
| Acid Value | Acid-Base Titration | Measures free carboxylic acid groups via titration with standardized KOH solution using phenolphthalein or potentiometric endpoint. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Hg, As) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Content | Ion Chromatography | Detects chloride ions by separation on anion-exchange column with conductivity detection after sample dissolution. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing (500-600 C) and weighing. |
| Optical Rotation | Polarimetry | Determines specific rotation using sodium D-line light to assess chiral purity and identity of the (2E)-isomer. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, confirming identity and crystallinity. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed sample to determine size distribution by measuring angular scattering of laser light. |
| Microbial Limits | Membrane Filtration | Detects aerobic bacteria, yeast, and mold using membrane filtration followed by incubation on appropriate agar media. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.3% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128.0–132.0°C |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Odor | Characteristic mild odor |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.