1-Cbz-(2R)-Methylpiperazine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 923565-99-5 |
| Product name | 1-Cbz-(2R)-Methylpiperazine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Cbz-(2R)-Methylpiperazine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Cbz-(2R)-Methylpiperazine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Cbz-(2R)-Methylpiperazine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing antipsychotic agents (e.g., aripiprazole analogues) | Used in asymmetric synthesis or chiral resolution, followed by coupling reactions, deprotection, and cyclization to construct the piperazine core structure |
| Pharmaceutical R&D | Chiral building blocks for constructing candidate drug molecules containing chiral piperazine scaffolds | Applied as C2-symmetric chiral ligands or substrates in transition metal-catalyzed C–N coupling and alkylation reactions |
Manufacturing Quality Control of 1-Cbz-(2R)-Methylpiperazine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-230 nm, comparing peak area to a certified reference standard. |
| Enantiomeric Purity | Chiral HPLC | Resolves (R)- and (S)-enantiomers on a chiral stationary phase; enantiomeric excess calculated from peak area ratio. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents (e.g., MeOH, EtOAc, toluene) using capillary GC with flame ionization detection. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Heavy Metals | ICP-MS | Detects trace metal impurities (e.g., Pd, Ni, Fe) after acid digestion by measuring elemental mass-to-charge ratios. |
| Chloride Content | Ion Chromatography | Quantifies chloride ions using suppressed conductivity detection after anion exchange separation. |
| Sulfate Content | Ion Chromatography | Quantifies sulfate ions using suppressed conductivity detection after anion exchange separation. |
| Residual Palladium | ICP-OES | Measures palladium catalyst residue post-hydrogenation using plasma excitation and atomic emission detection. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., de-benzylated product, diastereomers) using gradient HPLC-UV. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of solid or solution against established visual standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Loss on Drying | Gravimetric Method | Measures weight loss after drying under vacuum at specified temperature/time to determine volatile content. |
Technical Specifications of 1-Cbz-(2R)-Methylpiperazine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128°C to 132°C |
| Optical Rotation | +24.0° to +26.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Cbz-(2R)-Methylpiperazine
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| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Cbz-(2R)-Methylpiperazine
Packaging of 1-Cbz-(2R)-Methylpiperazine
Industrial 1-Cbz-(2R)-Methylpiperazine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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