2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 937595-71-6 |
| Product name | 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing antitumor, antiviral, or anti-inflammatory drugs | Used in Suzuki-Miyaura coupling to construct fluorinated pyridine scaffolds |
| Agrochemicals | Development of novel fluorinated heterocyclic insecticides or herbicides | Palladium-catalyzed cross-coupling to introduce specific functional groups for optimized biological activity |
| Materials Science | Precursor for organic optoelectronic materials (e.g., OLED emissive layer materials) | Boronic acid-mediated coupling to prepare π-conjugated systems with tailored electronic properties |
Manufacturing Quality Control of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
| Milestone | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection + Physical Property Measurement | Observe the sample's color, state (usually white to off-white crystalline or powder), determine the melting point range (literature value approximately 150–160 °C), and assess whether it is clumped, discolored, or contains impurities. |
| Purity of Main Component (Content Determination) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with water-methanol or acetonitrile gradient elution, and detect with a UV detector (wavelength 254 nm). Compare retention time with standard reference and quantify by peak area to calculate the content of the main component (≥95%). |
| Moisture Content | Karl Fischer Titration | Quantitatively react with water using an iodine-sulfur dioxide-pyridine-methanol system. Determine the moisture content using potentiometric or coulometric methods, ensuring that moisture content ≤1.0% to prevent hydrolysis of boric acid or affect stability. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection, with DB-624 or HP-INNOWAX column and FID detector to detect common organic solvents such as ethanol, acetone, ethyl acetate, in compliance with ICH Q3C limits. |
| Heavy Metal Impurities | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determine the content of heavy metals such as lead, cadmium, mercury, and arsenic using AAS or ICP-MS, keeping it within ≤10 ppm (according to pharmacopoeia standards such as USP/EP). |
| Chloride and Fluoride Ion Content | Ion Chromatography (IC) | Separate anions using an anion exchange column and detect Cl⁻ and F⁻ concentrations with a conductivity detector. Ensure no excessive inorganic halogen impurities to avoid affecting the activity of subsequent coupling reactions. |
| Boron Content | Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) | Determine total boron content after acid digestion using ICP-OES. Verify that the boron content matches the theoretical value (theoretical B content about 11.5%) to evaluate the integrity of the raw material. |
| Isomer and By-product Detection | HPLC-MS / LC-MS | Use high-resolution mass spectrometry to detect possible structural isomers (such as 2-chloro-4-fluoropyridine-3-boric acid), dehalogenated by-products, or oxidation products to ensure structural purity. |
| Solubility | Solubility Test | Determine solubility in common solvents such as water, ethanol, DMF, THF to confirm its applicability in the reaction system (usually slightly soluble in water, easily soluble in polar organic solvents). |
| Stability (Accelerated Test) | Accelerated Stability Test + HPLC Monitoring | Store at 40°C/75% RH for 1–4 weeks, and periodically take samples to monitor changes in the main peak area and the increase in impurities using HPLC, evaluating storage stability and setting the shelf life and storage conditions. |
Technical Specifications of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
Safety Information of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
Industrial 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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