4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 938066-17-2 |
| Product name | 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing pyrazole-containing targeted anticancer drugs (e.g., analogues of ALK inhibitors) | Employed as an iodinated heteroaryl substrate in coupling reactions (e.g., Suzuki or Heck couplings); the active molecular core is constructed following deprotection under acidic conditions |
| Agrochemical R&D | Applied as a heterocyclic modification fragment in designing novel insecticidal molecules | Specific substituents are introduced via transition-metal-catalyzed cross-coupling to optimize binding affinity toward insect target proteins |
| Organic Synthesis | Used as a multifunctional, protecting-group-modified pyrazole building block for constructing complex molecules | The N1 position of pyrazole is first protected with a THP group; the iodine atom participates in transition-metal-catalyzed reactions; the THP protecting group is subsequently removed using dilute hydrochloric acid or PPTS |
Manufacturing Quality Control of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by UV absorption at specific wavelength using reverse-phase chromatography with external standard calibration. |
| Related Substances | HPLC-UV | Detects and quantifies impurities (e.g., starting materials, intermediates, degradants) via gradient reverse-phase HPLC with UV detection. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., THF, DCM, MeOH) using gas chromatography with flame ionization detection and internal standard calibration. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration based on iodine consumption in a pyridine-free reagent system. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) using inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing and precise weighing. |
| Optical Rotation | Polarimetry | Determines specific rotation using sodium D-line light to assess chiral purity and identity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range of solid-to-liquid transition to verify identity and crystallinity. |
| Appearance | Visual Inspection | Evaluates physical state, color, and clarity against defined standards under controlled lighting. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed sample to determine size distribution profile using Mie scattering theory. |
| pH of Aqueous Suspension | pH Meter | Measures hydrogen ion activity in a standardized suspension (e.g., 1% w/v in water) using calibrated electrode. |
Technical Specifications of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 45–49 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Safety Information of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Industrial 4-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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