N-BOC-3-BROMOPYRROLIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 939793-16-5 |
| Product name | N-BOC-3-BROMOPYRROLIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-BOC-3-BROMOPYRROLIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-BOC-3-BROMOPYRROLIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-BOC-3-BROMOPYRROLIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing active pharmaceutical ingredients (APIs) containing a pyrrolidine moiety, such as neurokinin-1 (NK1) receptor antagonists and DPP-4 inhibitor antidiabetic agents | Applied in coupling reactions (e.g., Suzuki, Buchwald–Hartwig) or nucleophilic substitution reactions to construct chiral nitrogen-containing heterocyclic frameworks, following deprotection (TFA/DCM) and functional group transformations |
| Fine Chemicals | Used to prepare chiral catalyst ligands and functionalized pyrrolidine derivatives | Applied in palladium-catalyzed cross-coupling, lithium–halogen exchange followed by reaction with electrophiles, or selective bromination at specific sites to enable cyclization or alkylation |
| Materials Science | Used as a nitrogen-containing heterocyclic building block in organic optoelectronic materials, particularly for synthesizing novel OLED hole-transport materials | Applied in Suzuki coupling to introduce aryl groups, followed by N-BOC deprotection and quaternization to tune HOMO/LUMO energy levels |
Manufacturing Quality Control of N-BOC-3-BROMOPYRROLIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210-230 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., de-Boc, hydrolyzed, or isomeric byproducts) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Measures residual solvents (e.g., THF, DCM, MeOH) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine-based redox reaction in anhydrous methanol medium. |
| Residual Metals (e.g., Pd, Ni, Fe) | ICP-MS | Quantifies trace metal catalysts and contaminants by inductively coupled plasma mass spectrometry after acid digestion. |
| Optical Rotation | [alpha]D Measurement | Measures specific optical rotation at 589 nm using a polarimeter to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid phase transition using calibrated capillary apparatus per USP <741>. |
| Chloride Impurity | Ion Chromatography | Quantifies chloride ions via suppressed conductivity detection after separation on anion-exchange column. |
| Heavy Metals (Total) | USP <231> Sulfide Test | Semi-quantitative colorimetric comparison of sample solution with lead standard after sulfide precipitation under controlled pH. |
| Residual BOC Protecting Group | 1H NMR Spectroscopy | Confirms presence/absence of tert-butoxycarbonyl methyl protons (~1.4 ppm) and carbamate linkage integrity via quantitative proton integration. |
| pH of Solution (1% w/v in Water) | pH Meter | Measures aqueous solution acidity/basicity using calibrated glass electrode to assess hydrolytic stability and salt formation. |
| Particle Size Distribution | Laser Diffraction | Determines dry powder particle size distribution by measuring angular variation of laser light scattering intensity. |
Technical Specifications of N-BOC-3-BROMOPYRROLIDINE
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=99.0% (GC-MS) |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Optical Rotation | [α]²⁰D = -15.0 to -19.0° (c=1, in CHCl₃) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-BOC-3-BROMOPYRROLIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-BOC-3-BROMOPYRROLIDINE
Packaging of N-BOC-3-BROMOPYRROLIDINE
Industrial N-BOC-3-BROMOPYRROLIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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