tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 942271-61-6 |
| Product name | tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing antitumor agents (e.g., PARP inhibitors) | Multi-step synthesis—deprotection, amidation, and cyclization—in solid-phase or liquid-phase media to construct the target molecule’s core structure |
| Pharmaceutical R&D | Intermediate for synthesizing 5-HT2C receptor modulators | Palladium-catalyzed cross-coupling (e.g., Suzuki or Heck reaction) to introduce aryl/heteroaryl groups, followed by nitro reduction and diazotization-substitution to assemble the key pharmacophore |
| Pharmaceutical R&D | Intermediate for synthesizing JAK2 inhibitor derivatives | Selective nitro reduction to phenylenediamine, followed by condensation with sulfonyl chlorides or isocyanates, and final Boc group removal to complete active molecule assembly |
Manufacturing Quality Control of tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of structurally related impurities using gradient HPLC with UV detection and relative response factor correction. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on calibrated external standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated electrochemically to react stoichiometrically with water in the sample. |
| Heavy Metals | ICP-MS | Quantitative determination of trace metal elements (e.g., Pb, Cd, Ni, Fe) after acid digestion, using mass spectrometry detection. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions in solution after sample dissolution and filtration. |
| Residual Catalyst (Pd) | ICP-OES | Determination of palladium content after microwave-assisted acid digestion using optical emission spectroscopy at characteristic wavelengths. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing solid-to-liquid phase change under controlled heating rate. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral centers in solution at specified concentration and wavelength. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity as a function of angle to determine particle size distribution in a dispersed suspension. |
| Residue on Ignition | Gravimetric Analysis | Weighing of inorganic residue remaining after high-temperature ashing of the sample in a muffle furnace. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Determination of hydrogen ion activity in a standardized aqueous slurry using a calibrated glass electrode system. |
Technical Specifications of tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128°C to 132°C |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
Industrial tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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