2-AMINO-4-FLUOROPYRIDINE Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 944401-77-8 |
| Product name | 2-AMINO-4-FLUOROPYRIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 2-AMINO-4-FLUOROPYRIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-AMINO-4-FLUOROPYRIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-AMINO-4-FLUOROPYRIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a pharmaceutical intermediate in the synthesis of antitumor, antiviral, or neuroactive compounds | Constructs fluorinated heterocyclic structures via nucleophilic substitution, coupling reactions (e.g., Suzuki, Buchwald–Hartwig) |
| Agrochemicals | Used as an agrochemical intermediate in the synthesis of biologically active fluorinated pyridine derivatives | Introduces functional groups through halogen exchange, amination, or metal-catalyzed coupling |
| Materials Science | Used to prepare organic optoelectronic materials or ligand precursors | Acts as a nitrogen-containing ligand in metal complex synthesis or serves as a building block for π-conjugated systems |
Manufacturing Quality Control of 2-AMINO-4-FLUOROPYRIDINE
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection + Melting Point Determination | Observe sample color and physical state (typically white to off-white crystalline powder), and determine melting point range (literature value approximately 120–125°C) to assess purity and crystallinity. |
| Content Assay | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with mobile phase consisting of methanol-water or acetonitrile-buffer salt (e.g., phosphate buffer), detect using UV detector (254 nm or 280 nm), and quantify the main component by external standard method. This provides high precision and effective separation of impurities. |
| Impurity Profiling | HPLC (Gradient Elution) | Employ gradient elution to separate potential organic impurities (e.g., unreacted starting materials, defluorination by-products, oxidation products). Quantify impurity levels using peak area normalization or reference standard external calibration, in compliance with ICH Q3B guidelines. |
| Fluorine Content | Ion Chromatography (IC) or Fluoride Ion Selective Electrode | After alkaline hydrolysis or oxygen bomb combustion, release fluoride ions from the sample, then detect F⁻ concentration using ion chromatography or fluoride ion selective electrode to verify that the fluorine content matches theoretical values. |
| Water Content | Karl Fischer Titration | Utilize the iodine-sulfur dioxide-pyridine-methanol system for quantitative reaction with water, measured via potentiometric or coulometric methods. Determines trace moisture levels to ensure compliance with pharmaceutical standards (typically ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with DB-624 or HP-INNOWAX columns and FID detection to identify common organic solvent residues such as ethanol, acetonitrile, DMF, DMSO, meeting ICH Q3C requirements. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After acid digestion, determine levels of heavy metals (e.g., lead, cadmium, mercury, arsenic, copper) using AAS or ICP-MS, ensuring compliance with pharmacopoeial limits (e.g., Pb ≤ 10 ppm). |
| Chloride/Inorganic Anions | Ion Chromatography (IC) | Detect possible inorganic anions such as Cl⁻ and SO₄²⁻ introduced during synthesis, especially critical when chlorine-containing reagents are used, to prevent halogen contamination. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Measure characteristic absorption peaks (typically strong absorbance at 260–290 nm) in ethanol or methanol solution for preliminary identification and concentration estimation, supporting HPLC method validation. |
| Nuclear Magnetic Resonance (¹H NMR / ¹³C NMR) | Nuclear Magnetic Resonance Spectroscopy | Used for structural confirmation and purity assessment; confirm molecular structure based on characteristic proton signals (e.g., 2-NH₂, 4-F substituted pyridine ring protons) and integration ratios, and identify structural isomers. |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting point range as a physical constant for initial purity evaluation. A narrow melting range (≤2°C) indicates high purity; broad or low melting points suggest presence of impurities. |
Technical Specifications of 2-AMINO-4-FLUOROPYRIDINE
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 62–66°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 2-AMINO-4-FLUOROPYRIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-AMINO-4-FLUOROPYRIDINE
Packaging of 2-AMINO-4-FLUOROPYRIDINE
Industrial 2-AMINO-4-FLUOROPYRIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply