methyl 2-fluoro-3-nitrobenzoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 946126-94-9 |
| Product name | methyl 2-fluoro-3-nitrobenzoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for methyl 2-fluoro-3-nitrobenzoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk methyl 2-fluoro-3-nitrobenzoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of methyl 2-fluoro-3-nitrobenzoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key structural building block for synthesizing antitumor agents (e.g., EGFR inhibitors) | Introduces heterocyclic or aryl fragments via palladium-catalyzed cross-coupling reactions (e.g., Suzuki or Heck coupling) under inert atmosphere, followed by hydrolysis, reduction, and other steps to construct the active molecular scaffold |
| Pesticide R&D | Modification moiety for lead compounds in novel insecticides and fungicides | Converts nitro group to amino group via reduction, followed by diazotization and coupling with phenols or aromatic amines to produce fluorinated azo agrochemicals |
| Materials Science | Used to prepare fluorinated liquid crystal monomers and precursors for organic optoelectronic materials | Selectively reduces the nitro group and saponifies the ester group, then condenses with halogenated aromatic aldehydes to form liquid crystal core structures exhibiting rigidity and high dielectric anisotropy |
Manufacturing Quality Control of methyl 2-fluoro-3-nitrobenzoate
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Melting Point Determination | Observe sample color and physical state (typically white to pale yellow crystalline or powder); determine melting point range (literature value approximately 68–72 °C) to assess purity. |
| Content Determination (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with methanol-water or acetonitrile-water (containing 0.1% formic acid) as mobile phase, UV detector at 254 nm for detection, external standard method for quantification, ensuring main component content ≥98%. |
| Organic Impurities (Impurity Profile) | HPLC-UV / HPLC-MS | Utilize gradient elution HPLC to separate potential impurities (e.g., unreacted starting materials, hydrolysis products, isomers), combined with mass spectrometry (MS) for structural identification; control individual impurities ≤0.5%, total impurities ≤1.0%. |
| Fluorine Content | Ion Chromatography (IC) or Oxygen Bomb Combustion-Ion Selective Electrode | After oxygen bomb combustion, the sample is absorbed into alkaline solution and fluorine ion (F⁻) concentration is determined by ion chromatography or fluoride ion selective electrode; ensure compliance with theoretical value based on molecular formula (approximately 8.7% F). |
| Nitro Group Content Verification | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Determine absorbance peak at 270–280 nm characteristic of nitro group, using standard curve to verify presence and relative content of nitro group, supporting structural confirmation. |
| Residual Solvents | Gas Chromatography (GC-FID / GC-MS) | Test for common solvent residues such as methanol, ethyl acetate, dichloromethane according to ICH Q3C guidelines; use headspace injection with FID detection, ensuring compliance with specified limits (e.g., methanol ≤3000 ppm). |
| Moisture Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric Karl Fischer method; control moisture content ≤0.5% to prevent hydrolysis or crystallization abnormalities. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After wet digestion, determine levels of heavy metals such as lead, cadmium, mercury, and arsenic; comply with pharmaceutical-grade standards (e.g., Pb ≤5 ppm). |
| Melting Point | Capillary Melting Point Apparatus | Determine melting point range and compare with literature values (68–72 °C) to evaluate crystal form consistency and purity. |
| Inorganic Impurities (e.g., Chloride, Sulfate) | Colorimetric Method (Pharmacopoeia Procedures) | Follow general methods in the Chinese Pharmacopoeia: detect Cl⁻ and SO₄²⁻ via precipitation reactions using visual inspection or spectrophotometry; ensure levels remain within acceptable limits. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Nuclear Magnetic Resonance Spectroscopy (NMR) | Used for structural confirmation; characteristic peaks: δ 8.2–8.5 (Ar-H, ortho to NO₂), δ 7.6–7.8 (Ar-H, ortho to F), δ 3.95 (-OCH₃); integration ratios confirm molecular structure. |
Technical Specifications of methyl 2-fluoro-3-nitrobenzoate
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 65–69°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of methyl 2-fluoro-3-nitrobenzoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of methyl 2-fluoro-3-nitrobenzoate
Safety Information of methyl 2-fluoro-3-nitrobenzoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of methyl 2-fluoro-3-nitrobenzoate
Industrial methyl 2-fluoro-3-nitrobenzoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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