IGF-1 LR3 Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 946870-92-4 |
| Product name | IGF-1 LR3 |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for IGF-1 LR3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk IGF-1 LR3 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of IGF-1 LR3
| Industry | Application | Process |
|---|---|---|
| Biopharmaceutical Research | Insulin-like Growth Factor-1 Long Arginine 3 (IGF-1 LR3) serves as a tool molecule for modulating cell proliferation, differentiation, and anti-apoptotic signaling pathways, enhancing cell viability, extending passaging intervals, and increasing recombinant protein expression yield in vitro cell culture (e.g., CHO, HEK293, primary neurons) | Add IGF-1 LR3 to serum-free or low-serum culture media at a final concentration of 10–100 ng/mL; typically used in conjunction with transfection/infection steps or added during induction to improve target protein yield |
| Drug Development | Serves as a positive control probe targeting the IGF-1 receptor (IGF-1R) signaling pathway for high-throughput screening of IGF-1R inhibitors, evaluation of candidate compound antagonism against downstream AKT/mTOR signaling, and establishment of pharmacodynamic biomarker assays | In cellular pharmacodynamic assays (e.g., p-AKT ELISA, Western blot, reporter gene assays), pre-incubate cells for 15–30 minutes prior to adding test inhibitors, then stimulate with IGF-1 LR3 (50 ng/mL) and quantify signal inhibition |
| Regenerative Medicine Research | Promotes in vitro expansion and directed differentiation of mesenchymal stem cells (MSCs), muscle satellite cells, and chondrocytes, supporting scalable cell preparation prior to seeding onto tissue engineering scaffolds | Supplement basal media (e.g., DMEM/F12 + 1% BSA) with IGF-1 LR3 (25–75 ng/mL); combine with other factors (e.g., FGF-2, TGF-β3) to regulate differentiation, commonly applied in three-dimensional spheroid or hydrogel culture systems |
Manufacturing Quality Control of IGF-1 LR3
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | RP-HPLC with UV detection | Separation based on hydrophobicity; quantification via UV absorbance at 214 nm relative to reference standard |
| Related Substances | RP-HPLC with gradient elution | Detection and quantification of structurally related impurities (e.g., deamidated, oxidized, truncated forms) using retention time and peak area comparison |
| Peptide Content | UV-Vis spectrophotometry at 280 nm | Quantification based on absorbance of aromatic amino acid residues (Trp, Tyr) using molar extinction coefficient |
| Residual Solvents | Headspace GC-FID | Volatile organic solvents (e.g., acetonitrile, DMSO) quantified by gas chromatographic separation and flame ionization detection |
| Water Content | Karl Fischer titration | Electrochemical titration measuring water via iodine-sulfur dioxide reaction in anhydrous methanol-based medium |
| Endotoxin | Kinetic LAL assay | Quantitative measurement of endotoxin-induced clotting enzyme activation in Limulus amebocyte lysate |
| Bioburden | Membrane filtration followed by colony enumeration | Microbial load determined by filtration, membrane transfer to growth media, and CFU counting after incubation |
| Residual Host Cell Proteins | ELISA | Immunodetection using antibodies specific to host cell proteins (e.g., E. coli proteins) with colorimetric signal quantification |
| Residual DNA | qPCR | Amplification and quantification of conserved genomic sequences using fluorescent probes and cycle threshold analysis |
| Sterility | Direct inoculation into culture media (USP <71>) | Sample aseptically added to fluid thioglycollate and soybean-casein digest media; growth observed over 14 days |
| pH | Potentiometric pH measurement | Determination using calibrated glass electrode in aqueous solution at specified concentration and temperature |
| Appearance | Visual inspection | Assessment of solution clarity and color against water and platinum-cobalt standards under controlled lighting |
Technical Specifications of IGF-1 LR3
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
| Optical Rotation | -15.0° to -25.0° (c=1, 1M HCl) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of IGF-1 LR3
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| Lot/Batch Number | *Required fields | |
Packaging of IGF-1 LR3
Industrial IGF-1 LR3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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