Fmoc-Aib-OH Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 94744-50-0 |
| Product name | Fmoc-Aib-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-Aib-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-Aib-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-Aib-OH
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | As a non-natural amino acid, used for structural modification in peptide drug synthesis to enhance metabolic stability or biological activity | Employed as an Fmoc-protected building block in solid-phase peptide synthesis (SPPS), participating in stepwise coupling reactions |
| Biochemical Research | Used to construct model peptides containing α,α-dimethylglycine residues to study the impact of steric hindrance on peptide conformation and function | Integrated via standard Fmoc-SPPS using HBTU/HOBt or analogous coupling reagents for amide bond formation |
| Medicinal Chemistry | Serves as a key modifying component in peptide-based lead compounds to improve pharmacokinetic properties such as protease resistance | Introduced sequentially on automated peptide synthesizers, followed by deprotection and purification (HPLC) |
| Diagnostics Reagent Development | Used to synthesize highly stable peptide probes or labeled peptides for immunoassays or molecular imaging | Coupled with other functionalized amino acids after Fmoc deprotection; terminal functionalization with fluorescent or radioactive labels is feasible |
Manufacturing Quality Control of Fmoc-Aib-OH
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Inspect the sample by eye for color, physical state (e.g., white to off-white crystalline powder), and presence of visible foreign matter to determine compliance with appearance requirements. |
| Identification | Fourier Transform Infrared Spectroscopy (FT-IR) Nuclear Magnetic Resonance Proton Spectroscopy (¹H NMR) Retention time comparison using High-Performance Liquid Chromatography (HPLC) |
FT-IR: Measure the infrared absorption spectrum of the sample and compare it with a reference spectrum; ¹H NMR: Analyze characteristic chemical shifts and peak patterns to confirm molecular structure; HPLC: Compare the retention time of the sample with that of a reference standard under identical conditions. |
| Purity / Related Substances | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with gradient or isocratic elution to separate the main component from impurities. Calculate the purity of the main peak and the levels of individual impurities using area normalization or correction factor methods. Typically, total impurities should be ≤0.5%. |
| Assay | External Standard Method by HPLC Acid-Base Titration (less commonly used) |
HPLC external standard method: Establish a calibration curve using a reference standard of known concentration of Fmoc-2-aminoisobutyric acid, then calculate the assay based on the sample peak area. Typically, the assay should be between 98.0% and 102.0%. Titration may be suitable for amino acid derivatives without interfering groups, but due to interference from the Fmoc group, HPLC is generally preferred. |
| Water Content | Karl Fischer Titration | Quantify water content by the reaction between Karl Fischer reagent and water in the sample, using either coulometric or volumetric titration. Typically, water content should be ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection GC to detect residual organic solvents (e.g., dichloromethane, DMF, methanol) that may remain from synthesis or purification processes. Limits are controlled according to ICH Q3C guidelines. |
| Specific Optical Rotation | Polarimetry | Dissolve the sample in a solution of specified concentration and measure optical rotation at a defined wavelength (typically sodium D line, 589 nm) and temperature, then calculate specific optical rotation to assess chiral purity (if applicable). Note: 2-Aminoisobutyric acid is non-chiral; therefore, Fmoc-2-aminoisobutyric acid typically has no optical activity, and this test may not apply. |
| Melting Point | Capillary Melting Point Determination | Determine the temperature range from initial melting to complete melting using a melting point apparatus. Used as a physical constant for identification and purity assessment. |
Technical Specifications of Fmoc-Aib-OH
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 168–172°C |
| Optical Rotation | +14.0 to +16.0° (c=1, in DMF) |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-Aib-OH
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Industrial Fmoc-Aib-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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