(S)-N-Fmoc-1-Naphthylalanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 96402-49-2 |
| Product name | (S)-N-Fmoc-1-Naphthylalanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-N-Fmoc-1-Naphthylalanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-N-Fmoc-1-Naphthylalanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-N-Fmoc-1-Naphthylalanine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Chiral building block for solid-phase peptide synthesis (SPPS), used to introduce naphthyl-containing hydrophobic amino acid residues | Used as an Fmoc-protected non-natural amino acid monomer in SPPS; deprotected with piperidine and coupled to the resin-bound peptide chain via activated carboxyl groups |
| Pharmaceutical R&D | Hydrophobic anchoring domain in the design and synthesis of peptide inhibitors or PROTAC molecules targeting protein–protein interactions (PPIs) | Employed as a key chiral building block in multi-step solution-phase or solid-phase synthesis for structural optimization; the 1-naphthyl group enables π–π stacking to enhance target binding affinity |
| Chemical Biology | Preparation of fluorescently labeled or multivalent peptide probes, leveraging the intrinsic fluorescence of the naphthalene ring for bioimaging or binding assays | Modified selectively on the naphthalene ring (e.g., sulfonation, bromination) or conjugated at the C-terminus with fluorescent dyes, then incorporated into functionalized peptide sequences via Fmoc-based synthesis |
Manufacturing Quality Control of (S)-N-Fmoc-1-Naphthylalanine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by UV absorption at 268 nm using reverse-phase C18 column and gradient elution with acetonitrile/water/TFA. |
| Chiral Purity | Chiral HPLC | Resolves enantiomers on a chiral stationary phase (e.g., Chirobiotic T) to confirm L-configuration and detect D-isomer impurity. |
| Water Content | Karl Fischer Titration | Measures trace water via coulometric or volumetric titration with iodine generated electrochemically in pyridine-free reagent. |
| Residual Solvents | GC-FID | Detects and quantifies residual solvents (e.g., DMF, dichloromethane, methanol) using capillary column and flame ionization detection. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (Pb, Cd, Hg, As, etc.) at sub-pptr levels after acid digestion and plasma ionization. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., Fmoc-Gly, deprotected alanine, naphthyl side-product) using optimized gradient method. |
| Optical Rotation | [alpha]D Measurement | Determines specific rotation at 589 nm using sodium D-line lamp to verify chiral integrity and batch-to-batch consistency. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range of solid-to-liquid transition to assess crystallinity and purity (sharp melting indicates high purity). |
| Loss on Drying | Gravimetric Heating | Determines volatile content by weight loss after drying at 60 C under vacuum for 2 hours. |
| pH of Solution | Potentiometric pH Measurement | Measures pH of 1% w/v aqueous suspension (or solution in water/THF mixture) using calibrated pH electrode. |
| Appearance | Visual Inspection | Assesses physical state, color, and homogeneity against standard reference; white to off-white crystalline powder expected. |
| Residue on Ignition | Sulfated Ash Test | Determines inorganic residue mass after ignition at 700–750 C following sulfuric acid treatment. |
Technical Specifications of (S)-N-Fmoc-1-Naphthylalanine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | -61° to -57° (c=1, DMF) |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-N-Fmoc-1-Naphthylalanine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-N-Fmoc-1-Naphthylalanine
Packaging of (S)-N-Fmoc-1-Naphthylalanine
Industrial (S)-N-Fmoc-1-Naphthylalanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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