Ademetionine disulfate tosylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 97540-22-2 |
| Product name | Ademetionine disulfate tosylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ademetionine disulfate tosylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ademetionine disulfate tosylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ademetionine disulfate tosylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Active pharmaceutical ingredient (API) for the treatment of depression, intrahepatic cholestasis, and osteoarthritis | Pharmaceutical formulation processes (e.g., tablet compression, lyophilized powder injection preparation); commonly converted to a salt with p-toluenesulfonic acid to enhance stability |
| Dietary Supplements | Dietary supplement ingredient for mood support, liver health maintenance, and joint care | Blending and granulation, tablet compression, or capsule filling; enteric coating technology applied to improve bioavailability |
| Biochemical Research | Methyl donor in in vitro enzymatic reactions and studies of biosynthetic pathways | Enzyme-catalyzed reaction system construction; supplementation into cell culture media |
| Chemical Synthesis | Key intermediate or catalyst in biocatalytic synthesis and chemical modification of chiral drugs | Enzymatic synthesis, chiral resolution, and biotransformation processes |
| Cosmetics Industry | Functional additive in antioxidant and anti-aging skincare formulations | Emulsion mixing; liposomal encapsulation |
Manufacturing Quality Control of Ademetionine disulfate tosylate
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection, Melting Point Determination | Observe sample appearance (e.g., white or off-white powder), solubility (freely soluble in water, slightly soluble in ethanol), and determine melting point range (typically 160–170°C, decomposition) to confirm purity and crystal form. |
| Identification | Infrared Spectroscopy (IR), High-Performance Liquid Chromatography (HPLC) | IR: Compare characteristic functional group absorption peaks (e.g., adenosine, methionine, p-toluenesulfonate) with reference spectra; HPLC: Match retention time with reference standard for structural confirmation. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use C18 column, mobile phase of phosphate buffer-methanol (e.g., 70:30), UV detection at 254 nm; calculate content of S-adenosylmethionine p-toluenesulfonate using external standard method, typically requiring ≥98.0%. |
| Related Substances | High-Performance Liquid Chromatography (HPLC) | Same conditions as content determination, using gradient or isocratic elution to detect degradation products (e.g., S-adenosylhomocysteine, adenosine, methionine). Single impurity ≤0.5%, total impurities ≤1.0%. |
| Water Content | Karl Fischer Titration (KF) | Determine moisture content using volumetric or coulometric KF titration; control within ≤3.0% to prevent hygroscopicity-induced stability issues. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH Q3C guidelines, detect residual solvents such as methanol, ethanol, acetone, ethyl acetate using headspace injection and FID detection; ensure compliance with specified limits (e.g., methanol ≤3000 ppm). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detect heavy metals including lead, cadmium, mercury, and arsenic; limit set at ≤10 ppm (per pharmacopoeia general rules) to ensure safety. |
| Sulfate and p-Toluenesulfonate Content | Ion Chromatography (IC) or Precipitation Titration | IC: Separate and quantify sulfate (SO₄²⁻) and p-toluenesulfonate (p-TsO⁻); ensure molar ratio matches chemical formula (typically 1:1); precipitation method: precipitate sulfate with barium chloride and calculate by weight. |
| pH Value | pH Meter Measurement | Prepare a 1% aqueous solution of the sample and measure pH, typically within the range of 5.0–7.0, ensuring formulation stability and biocompatibility. |
| Microbial Limits | Plate Count Method / Membrane Filtration Method (per Pharmacopoeia) | Test for total aerobic bacteria count, mold and yeast count, Escherichia coli, Salmonella, etc.; comply with microbial limits for non-sterile products (e.g., total aerobic bacteria ≤10³ CFU/g). |
| Particle Size Distribution (if applicable) | Laser Diffraction Method | For powder formulations, assess particle size distribution (D50) to ensure uniformity and compressibility; generally controlled with D90 < 100 μm. |
| Solution Clarity and Color | Visible Spectrophotometry or Visual Color Comparison | Prepare solution at specified concentration and compare with standard colorimetric solutions; ensure no turbidity or abnormal color (e.g., yellow), meeting pharmacopoeial requirements. |
Technical Specifications of Ademetionine disulfate tosylate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 185–190°C (decomposes) |
| Optical Rotation | -25° to -35° (c=1, H2O) |
| Residue on Ignition | <=0.2% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ademetionine disulfate tosylate
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NMR Spectra of Ademetionine disulfate tosylate
Safety Information of Ademetionine disulfate tosylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Ademetionine disulfate tosylate
Industrial Ademetionine disulfate tosylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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