2-chloro-5-Methyl-4-nitropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 97944-45-1 |
| Product name | 2-chloro-5-Methyl-4-nitropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-chloro-5-Methyl-4-nitropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-chloro-5-Methyl-4-nitropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-chloro-5-Methyl-4-nitropyridine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Key intermediate in the synthesis of the insecticide imidacloprid | Further converted into active ingredients via nucleophilic substitution, reduction, or coupling reactions |
| Pharmaceuticals | Used to synthesize biologically active nitrogen-containing heterocyclic compounds, such as lead structures for potential antitumor or antibacterial agents | Employed as a building block in multistep organic synthesis, including Suzuki coupling and amination reactions |
| Fine Chemicals | Organic synthesis intermediate for preparing other functionalized pyridine derivatives | Derivatized via processes such as nitro group reduction, chlorine atom substitution, or methyl group functionalization |
Manufacturing Quality Control of 2-chloro-5-Methyl-4-nitropyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~254 nm, based on peak area comparison against a certified reference standard. |
| Related Substances (Impurities) | HPLC-UV or UPLC-MS | Separation and quantification of structurally related impurities (e.g., isomers, nitro-reduction byproducts, chlorination intermediates) using gradient elution and UV or mass-selective detection. |
| Residual Solvents | GC-FID or GC-MS | Headspace GC analysis with flame ionization or mass spectrometric detection to quantify residual solvents (e.g., dichloromethane, toluene, methanol) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based medium. |
| Heavy Metals | ICP-MS or ICP-OES | Quantification of elemental impurities (e.g., Pb, Cd, As, Hg) after acid digestion, per ICH Q3D, using inductively coupled plasma mass spectrometry or optical emission spectroscopy. |
| Chloride Ion (Inorganic Chloride) | Ion Chromatography (IC) or Potentiometric Titration | Separation and quantification of Cl⁻ ions via suppressed conductivity detection (IC) or argentometric titration with AgNO₃ endpoint detection. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Analysis | Incineration at 700–800 °C followed by sulfuric acid treatment and weighing of non-volatile inorganic residue. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid phase transition temperature using calibrated capillary apparatus per USP <741>. |
| Appearance and Color | Visual Inspection / APHA Color Scale | Subjective assessment of crystalline form and color intensity compared against APHA platinum-cobalt standards. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion via light scattering to determine D10, D50, D90 values per ISO 13320. |
| Bulk and Tapped Density | ASTM D6393 | Measurement of mass per unit volume under controlled tapping conditions to assess flowability and packing behavior. |
| Organic Volatile Impurities (e.g., Nitrobenzene, Chloropyridines) | GC-MS | Targeted screening and quantification of genotoxic impurities using selective ion monitoring after headspace or solvent extraction. |
| Optical Rotation | Polarimetry | Measurement of specific rotation at specified wavelength (e.g., 589 nm) and concentration to confirm chiral purity (if applicable; compound is achiral, but used for identity verification). |
Technical Specifications of 2-chloro-5-Methyl-4-nitropyridine
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 78–82°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-chloro-5-Methyl-4-nitropyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-chloro-5-Methyl-4-nitropyridine
Safety Information of 2-chloro-5-Methyl-4-nitropyridine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-chloro-5-Methyl-4-nitropyridine
Industrial 2-chloro-5-Methyl-4-nitropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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