5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 97963-62-7 |
| Product name | 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for proton pump inhibitors such as omeprazole | Participates in drug synthesis via nucleophilic substitution, oxidation, or cyclization |
| Chemical Synthesis | Organic building block for constructing benzimidazole-containing compounds | Coupling or condensation reactions with alkyl halides or acyl chlorides under inert atmosphere |
| Drug Discovery | Development of novel anti-ulcer agents or gastric acid secretion inhibitors | Structural modification followed by biological activity screening and structure–activity relationship (SAR) studies |
Manufacturing Quality Control of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 chromatographic column, with water–acetonitrile or methanol as the mobile phase for gradient elution. Detection is performed using a UV detector at wavelengths of 254–280 nm. The main component content is calculated by external standard method or area normalization method, and the purity is typically required to be ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Using the same HPLC system as for purity testing, but optimizing the gradient program to separate structurally similar impurities (e.g., oxidation products, de-sulfurized products, unreacted raw materials). Combined with mass spectrometry (MS), unknown impurities can be identified. Control single impurity ≤0.1%, total impurities ≤0.5%. |
| Moisture Content | Karl Fischer Titration | Based on the quantitative reaction between iodine–sulfur dioxide–pyridine–methanol system and water, measured via potentiometric or coulometric methods. Suitable for samples that are difficult to dissolve in organic solvents, moisture content is usually controlled to ≤0.5% (depending on dosage form requirements). |
| Residual Solvents | Gas Chromatography (GC) | Using headspace or direct injection with capillary columns (e.g., DB-624) to separate common organic solvents (e.g., methanol, ethanol, acetonitrile, dichloromethane), quantified with FID detector. Residual solvent levels are controlled according to ICH Q3C standards. |
| Heavy Metals and Harmful Elements | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion with microwave, ICP-MS is used to determine the content of heavy metals such as Pb, Cd, Hg, As, Cu, complying with pharmacopoeia requirements (e.g., USP <232>, EP 2.5.12) for elemental impurities. |
| Melting Point | Melting Point Apparatus | Determine melting point range using capillary or thermal analysis methods. Typical values are 145–152°C (literature value), used for preliminary identification and batch consistency evaluation. |
| Infrared Identification (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Determine the IR absorption spectrum of the sample, comparing characteristic peaks (e.g., N–H stretching ~3400 cm⁻¹, C=S stretching ~1200 cm⁻¹, C–F stretching ~1100–1200 cm⁻¹) with reference spectra for structural confirmation. |
| Thin Layer Chromatography (TLC) | Thin Layer Chromatography | Using silica gel G plates with developing solvent such as ethyl acetate: n-hexane (3:1), visualized under UV light (254 nm) or iodine vapor. Used for rapid qualitative screening of main components and major impurities, serving as an auxiliary method. |
| Sulfhydryl Group (–SH) Content | Iodometric Titration or HPLC-ED (Electrochemical Detection) | Utilizing the quantitative reaction between sulfhydryl groups and iodine, calculating free sulfhydryl content based on consumed iodine; alternatively, HPLC with electrochemical detection (ECD) can directly detect sulfhydryl compounds with high sensitivity, used to evaluate oxidation stability. |
| Solubility | Shake Flask Method | Determine equilibrium solubility in different pH buffer solutions (e.g., pH 1.2, 4.5, 6.8) and water, providing data for formulation development. This compound is generally slightly soluble in water, highly soluble in DMSO and ethanol. |
Technical Specifications of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
| Test Item | Specification |
|---|---|
| Appearance | White to orange to green powder to crystal |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–215 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
Safety Information of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
Industrial 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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