Pyrazinamide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 98-96-4 |
| Product name | Pyrazinamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Pyrazinamide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Pyrazinamide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Pyrazinamide
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Antitubercular agent for treating tuberculosis, typically administered in combination with other antitubercular drugs (e.g., isoniazid, rifampicin) | Used as a prodrug; hydrolyzed in vivo by pyrazinamidase to the active metabolite pyrazinoic acid, which disrupts fatty acid synthesis and energy metabolism in Mycobacterium tuberculosis |
| Pharmaceutical R&D | Used in the development of novel antitubercular compounds and combination formulations | Applied in structural modification or co-crystallization with other active molecules to optimize pharmacokinetic properties and antibacterial spectrum |
| Analytical Chemistry | Used as a reference standard or control substance for drug quality control and testing | Employed as a quantitative and qualitative reference in high-performance liquid chromatography (HPLC) or mass spectrometry analysis |
Manufacturing Quality Control of Pyrazinamide
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Perform infrared scanning of the sample and reference standard under identical conditions, and compare characteristic absorption peaks to confirm chemical structure consistency. |
| Ultraviolet-Visible Spectrophotometry (UV-Vis) | Utilize the characteristic absorption of pyrazinamide at a specific wavelength (e.g., around 268 nm) to identify the substance based on its maximum absorption wavelength. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with a mobile phase such as methanol-water or buffer solution; detect with a UV detector and quantify the main component using the external standard method. |
| Ultraviolet Spectrophotometry (UV) | Measure absorbance at 268 nm and calculate content based on a standard calibration curve; suitable for rapid quantification of the active ingredient in formulations. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate and detect impurities such as pyrazinoic acid, isonicotinic acid, and other degradation products using gradient or isocratic elution; calculate the content of each impurity. |
| Water Content | Karl Fischer Titration | Determine residual moisture content in the active pharmaceutical ingredient using Karl Fischer reagent for titration. |
| Solution Clarity | Visual Turbidity Comparison | Dissolve the sample in the specified solvent and compare visually with a standard turbidity solution to assess whether the solution is clear. |
| Solution Color | Visual Color Comparison / Spectrophotometry | Compare with standard color solutions or scan in the visible region to evaluate whether the solution color meets the specified limits. |
| Heavy Metals | Sulfide Colorimetric Method (Chinese Pharmacopoeia Method) | Under acidic conditions, react with sodium sulfide to form a colored precipitate; compare with a standard lead solution to control total heavy metal content. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Oven Method | Dry the sample to constant weight at a specified temperature and measure the weight loss to reflect volatile impurities and residual solvents. |
| Residue on Ignition | Ignition Method | Ignite the sample at high temperature and weigh the residual ash to determine inorganic impurity content. |
| Crystalline Form Analysis | X-ray Powder Diffraction (XRD) | Analyze characteristic crystalline peaks of the sample to identify different polymorphic forms and ensure batch consistency. |
| Particle Size Distribution | Laser Diffraction Particle Size Analysis | Determine particle size distribution using laser scattering principles; influences dissolution rate and formulation performance. |
Technical Specifications of Pyrazinamide
| Test Item | Specification |
|---|---|
| Appearance | White to almost white crystalline powder |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 189.0–193.0°C |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Pyrazinamide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Pyrazinamide
Packaging of Pyrazinamide
Industrial Pyrazinamide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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