protamine sulfate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 98001-69-5 |
| Product name | protamine sulfate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for protamine sulfate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk protamine sulfate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of protamine sulfate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Antidote for heparin overdose | Used as a specific antagonist to neutralize heparin’s anticoagulant activity via electrostatic binding, thereby terminating heparin anticoagulation during cardiopulmonary bypass or hemodialysis. |
| Pharmaceutical Industry | Long-acting insulin formulations | Employed as a carrier protein to form protamine zinc insulin (PZI) or neutral protamine Hagedorn (NPH) insulin, thereby delaying insulin release and extending glycemic control duration. |
| Biotechnology | Gene transfection vector | Utilized for its cationic properties to condense DNA or RNA into nanoscale complexes, facilitating nucleic acid delivery into cells for transfection assays or gene therapy research. |
| Biopharmaceuticals | Protein separation and purification | Applied as an affinity ligand or precipitant to isolate and purify specific proteins from mixtures (e.g., removal of heparin from formulations or isolation of specific enzymes). |
| Biochemical Research | Zymogen activation | Used in biochemical assays to activate specific zymogens, such as prekallikrein. |
Manufacturing Quality Control of protamine sulfate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Protein Content) | UV-Vis Spectrophotometry at 280 nm | Measures absorbance of aromatic amino acids (Trp, Tyr) to quantify protein concentration based on Beer-Lambert law. |
| Identity | SDS-PAGE with Coomassie Staining | Separates proteins by molecular weight under denaturing conditions; confirms identity by band migration relative to reference standard. |
| Purity (Related Proteins) | Reversed-Phase HPLC | Resolves impurities and degradation products using hydrophobic interaction with C18 column and UV detection. |
| Residual Solvents (e.g., Acetonitrile, Methanol) | Gas Chromatography (GC) with FID | Quantifies volatile organic solvents by separation in capillary column and flame ionization detection. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Detects trace metal elements by plasma ionization and mass spectrometric quantification with high sensitivity and multi-element capability. |
| Residual Host Cell Proteins (HCP) | ELISA | Uses antibodies specific to host cell proteins to detect and quantify HCP impurities via enzymatic colorimetric signal. |
| Endotoxin Level | Kinetic Turbidimetric LAL Assay | Measures endotoxin-induced clotting enzyme cascade in Limulus amebocyte lysate, quantified by turbidity development rate. |
| Bioburden | Membrane Filtration with TSA Plating | Captures viable microorganisms on filter membrane, followed by incubation on Tryptic Soy Agar for colony enumeration. |
| Sterility | Direct Inoculation into Fluid Thioglycollate Medium and Soybean-Casein Digest Medium | Inoculates sample into growth media supporting aerobic/anaerobic and fungal growth; absence of turbidity after incubation confirms sterility. |
| pH | Potentiometric pH Measurement | Determines hydrogen ion activity using calibrated glass electrode and pH meter in aqueous solution. |
| Water Content | Karl Fischer Coulometric Titration | Quantifies water via electrochemical generation of iodine reacting stoichiometrically with water in anhydrous methanol-based medium. |
| Osmolality | Freezing Point Depression Osmometry | Measures osmotic concentration by determining the depression of freezing point of aqueous solution relative to pure water. |
Technical Specifications of protamine sulfate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.5% |
| Optical Rotation | +25° to +35° (c=1, 1M HCl) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of protamine sulfate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of protamine sulfate
Industrial protamine sulfate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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