N-boc Asp(OH)Ome Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 98045-03-5 |
| Product name | N-boc Asp(OH)Ome |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-boc Asp(OH)Ome
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-boc Asp(OH)Ome Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-boc Asp(OH)Ome
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | As a protecting reagent for aspartic acid residues in peptide synthesis, applied in solid-phase or solution-phase synthesis of anticancer, antiviral, and hormonal drugs (e.g., leuprorelin, octreotide) | Selectively protects the side-chain carboxyl group (β-position) of aspartic acid in Fmoc/tBu strategies to prevent side reactions; methyl esterification stabilizes the α-carboxyl group to facilitate subsequent coupling; deprotection is performed using a trifluoroacetic acid (TFA)/dichloromethane system |
| Biotechnology | Used to prepare structurally defined peptide probes, enzyme substrates, and linker-payload intermediates in antibody–drug conjugates (ADCs) | Coupled with amine components via condensation after activation with DIC/HOBt on automated peptide synthesizers; reaction conditions are mild (0–25 °C, in DMF or NMP solvent) |
| Fine Chemicals | As a chiral building block incorporated into structural units of novel protease inhibitors and targeted degraders (e.g., PROTACs) | Functional group exposure sequence is controlled via palladium-catalyzed cross-coupling or selective hydrolysis (LiOH/THF–H₂O) to enable modular assembly |
Manufacturing Quality Control of N-boc Asp(OH)Ome
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification by retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, ethyl acetate) via headspace GC with flame ionization detection using internal standard calibration. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration where iodine reacts stoichiometrically with water in a controlled electrochemical or chemical system. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pb, Cd, Ni) after acid digestion using inductively coupled plasma mass spectrometry with isotope dilution. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after anion exchange separation with carbonate eluent. |
| Residual Palladium | ICP-OES | Measures palladium residue from catalytic hydrogenation steps via microwave-assisted digestion followed by inductively coupled plasma optical emission spectroscopy. |
| Optical Rotation | [alpha]D Measurement | Determines specific optical rotation using sodium D-line light source to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, indicating crystallinity and presence of impurities. |
| Particle Size Distribution | Laser Diffraction | Analyzes particle size distribution in dry or wet dispersion by measuring angular intensity of scattered laser light. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Measures hydrogen ion activity in a defined suspension (e.g., 1% w/v in water) using calibrated glass electrode and pH meter. |
| Microbial Limits | Membrane Filtration | Quantifies aerobic microorganisms and detects specified pathogens (e.g., E. coli, S. aureus) by filtration, culture on selective media, and colony enumeration. |
Technical Specifications of N-boc Asp(OH)Ome
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 128°C to 133°C |
| Optical Rotation | -23.0° to -20.0° (c=1, in 1M HCl) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-boc Asp(OH)Ome
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-boc Asp(OH)Ome
Packaging of N-boc Asp(OH)Ome
Industrial N-boc Asp(OH)Ome Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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