Benzo[b]thien-2-ylboronic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 98437-23-1 |
| Product name | Benzo[b]thien-2-ylboronic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Benzo[b]thien-2-ylboronic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Benzo[b]thien-2-ylboronic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Benzo[b]thien-2-ylboronic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in the synthesis of targeted anticancer drugs (e.g., BTK inhibitors) | Applied in Suzuki-Miyaura cross-coupling reactions |
| Materials Science | Used to prepare hole-transport layers for organic light-emitting diodes (OLEDs) and optoelectronic functional materials | Applied in palladium-catalyzed C–C coupling to construct conjugated fused-ring frameworks |
| Agrochemical R&D | Used as a structural building block in the design and synthesis of novel insecticidal molecules | Applied in transition-metal-catalyzed arylation to introduce benzothiophene boronic acid moieties |
Manufacturing Quality Control of Benzo[b]thien-2-ylboronic acid
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | A reversed-phase C18 chromatographic column is used with methanol/water or acetonitrile/water as the mobile phase. A UV detector (typically at around 254 nm) is employed for detection, and the purity of benzothiophene-2-boronic acid is calculated by external standard method or area normalization method. |
| Impurities (Organic Impurities) | High-Performance Liquid Chromatography (HPLC) | The same HPLC conditions are applied to separate and quantify possible by-products (such as unreacted raw materials, de-boronated products, oxidation products, etc.), evaluating the impurity profile and total impurity content. |
| Moisture | Karl Fischer Titration | Iodine and sulfur dioxide react quantitatively with water in a pyridine/methanol system. The moisture content of the sample is determined by coulometric or volumetric titration, suitable for boronic acid compounds sensitive to moisture. |
| Residual Solvents | Gas Chromatography (GC) | Headspace injection or direct injection is used with an FID detector. According to ICH Q3C guidelines, residual organic solvents from synthesis or purification processes (e.g., toluene, dichloromethane, ethanol, etc.) are detected. |
| Melting Point | Melting Point Determination | A melting point apparatus or capillary method is used to determine the melting temperature range of the sample, serving as a preliminary physical indicator for assessing purity and crystallinity consistency. |
| Elemental Impurities (e.g., Heavy Metals) | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | After sample digestion, metal catalyst residues potentially introduced (e.g., palladium, nickel, etc.) are detected, complying with ICH Q3D requirements for elemental impurity control. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR), Infrared Spectroscopy (IR), Mass Spectrometry (MS) | ¹H NMR and ¹³C NMR are used to confirm molecular structure; IR identifies characteristic functional groups (e.g., B–OH, C–S); MS (ESI or EI) verifies molecular weight and fragmentation information, used for identity identification of active pharmaceutical ingredients or key intermediates. |
| pH Value (If Dissolved in Solution) | pH Meter Measurement | The sample is dissolved into a certain concentration aqueous solution, and its acidity or alkalinity is measured using a calibrated pH meter, assisting in evaluating the dissociation behavior and stability of the boronic acid group. |
Technical Specifications of Benzo[b]thien-2-ylboronic acid
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 75–79°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Benzo[b]thien-2-ylboronic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Benzo[b]thien-2-ylboronic acid
Safety Information of Benzo[b]thien-2-ylboronic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Benzo[b]thien-2-ylboronic acid
Industrial Benzo[b]thien-2-ylboronic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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