(E)-4-(diMethylaMino)but-2-enoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 98548-81-3 |
| Product name | (E)-4-(diMethylaMino)but-2-enoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (E)-4-(diMethylaMino)but-2-enoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (E)-4-(diMethylaMino)but-2-enoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (E)-4-(diMethylaMino)but-2-enoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in synthesizing linkers for antitumor drugs such as the trastuzumab emtansine (T-DM1) conjugate | Employed as a key intermediate in conjugation reactions to construct cleavable linker structures via amidation, hydrolysis, and related steps |
| Pharmaceutical Intermediates | Used as a side-chain modification unit in candidate protein kinase inhibitors | Introduced via esterification/amidation to incorporate an unsaturated carboxylic acid bearing a dimethylamino group, enhancing target selectivity and metabolic stability |
Manufacturing Quality Control of (E)-4-(diMethylaMino)but-2-enoic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Acid-Base Titration | Quantifies the main compound by titration with standardized NaOH using an indicator or potentiometric endpoint. |
| Water Content | Karl Fischer Titration | Measures water via iodine-sulfur dioxide reaction in a methanol-based solvent system. |
| Residual Solvents | Gas Chromatography (GC) | Separates and quantifies volatile organic solvents using a capillary column and FID detection. |
| Heavy Metals | ICP-OES | Determines trace metal impurities (e.g., Pb, Cd, Ni) by plasma excitation and elemental emission spectroscopy. |
| Chloride Impurity | Ion Chromatography (IC) | Separates and quantifies chloride ions using an anion-exchange column and conductivity detection. |
| Related Substances | HPLC with UV Detection | Resolves and quantifies structurally related impurities using reversed-phase chromatography and UV absorbance at 210 nm. |
| Optical Rotation | Polarimetry | Measures specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| pH of Aqueous Solution | pH Meter Measurement | Determines acidity/basicity of a defined aqueous solution using calibrated glass electrode. |
| Loss on Drying (LOD) | Gravimetric Thermogravimetry | Measures volatile content by weight loss after controlled heating under specified temperature and time. |
| Residue on Ignition | Sulfated Ash Test | Quantifies non-volatile inorganic residue after high-temperature ignition following sulfuric acid treatment. |
| Particle Size Distribution | Laser Diffraction | Analyzes size distribution of solid particles in suspension using angular scattering pattern of laser light. |
| Microbial Limits | Membrane Filtration and Culture | Detects and enumerates aerobic microorganisms using filtration, membrane transfer, and incubation on nutrient agar. |
Technical Specifications of (E)-4-(diMethylaMino)but-2-enoic acid
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Acid Value (mg KOH/g) | 220-240 mg KOH/g |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (E)-4-(diMethylaMino)but-2-enoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (E)-4-(diMethylaMino)but-2-enoic acid
Safety Information of (E)-4-(diMethylaMino)but-2-enoic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (E)-4-(diMethylaMino)but-2-enoic acid
Industrial (E)-4-(diMethylaMino)but-2-enoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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