DMT-dA(bz) Phosphoramidite Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 98796-53-3 |
| Product name | DMT-dA(bz) Phosphoramidite |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for DMT-dA(bz) Phosphoramidite
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk DMT-dA(bz) Phosphoramidite Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of DMT-dA(bz) Phosphoramidite
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Adenine (A) monomer reagent for solid-phase DNA oligonucleotide synthesis, used to introduce a protected 2'-deoxyadenosine unit | Used as a phosphoramidite monomer in automated DNA synthesizers; oligonucleotide chain elongation proceeds in the 3'→5' direction via cyclic steps of deprotection (DMT removal with trichloroacetic acid), coupling (reaction of the activated monomer—e.g., with tetrazole—with the free 5'-OH group), capping (acetic anhydride/1-methylimidazole), and oxidation (iodine/water/pyridine) |
Manufacturing Quality Control of DMT-dA(bz) Phosphoramidite
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 260 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities (e.g., diastereomers, hydrolysis products) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., acetonitrile, dichloromethane, THF) based on retention time and flame ionization response. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine to determine water content based on stoichiometric reaction with Karl Fischer reagent. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using a polarimeter to confirm chiral integrity and absence of racemization. |
| Acid Number | Acid-Base Titration | Titration with standardized NaOH solution to quantify acidic impurities (e.g., residual phosphonic acids or hydrolyzed phosphoramidite). |
| Phosphorus Content | ICP-OES | Quantitative determination of total phosphorus after acid digestion, using inductively coupled plasma optical emission spectroscopy. |
| Heavy Metals | ICP-MS | Multi-element detection of toxic metals (e.g., Pd, Ni, Cu) at trace levels following microwave-assisted acid digestion. |
| Residual Catalyst (Pd) | ICP-OES | Specific quantification of palladium residues from coupling steps using characteristic emission lines after sample digestion. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution via light scattering patterns generated by dispersed particles in air. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic microorganisms by filtration, membrane transfer to culture media, and colony counting after incubation. |
| Endotoxin Level | LAL Assay | Quantification of bacterial endotoxins using Limulus amebocyte lysate reactivity, measured photometrically or turbidimetrically. |
Technical Specifications of DMT-dA(bz) Phosphoramidite
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | -6.5 to -5.5 deg (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of DMT-dA(bz) Phosphoramidite
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of DMT-dA(bz) Phosphoramidite
Packaging of DMT-dA(bz) Phosphoramidite
Industrial DMT-dA(bz) Phosphoramidite Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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