4-Cyanopyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 100-48-1 |
| Product name | 4-Cyanopyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Cyanopyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Cyanopyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Cyanopyridine
| Industry | Application | Process |
|---|---|---|
| Pesticide Industry | Synthesis of pesticide intermediates | Prepared via cyanation of the pyridine ring |
| Pharmaceutical Industry | Synthesis of pharmaceutical intermediates | Used in the synthesis of antitubercular and antifungal agents |
| Fine Fragrance Industry | Synthesis of fragrance intermediates | Serves as a precursor for synthesizing certain aromatic compounds |
| Organic Synthesis | Synthesis of other nitrogen-containing heterocyclic compounds | Further modified via nucleophilic substitution or coupling reactions |
Manufacturing Quality Control of 4-Cyanopyridine
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 reversed-phase column with methanol/water or acetonitrile/water as the mobile phase, and UV detection (220–254 nm). Quantification of the main component is performed via external standard or internal standard method to assess purity. |
| Impurity Profile (Organic Impurities) | HPLC-UV / HPLC-MS | After HPLC separation, UV detection identifies major impurity peaks; mass spectrometry (MS) is used for structural elucidation, such as unreacted starting materials (pyridine, 4-chloropyridine), by-products (dimers, oxides), etc. |
| Water Content | Karl Fischer Titration | Employs an iodine-sulfur dioxide-pyridine-methanol system that reacts quantitatively with water. Measured via electrochemical or volumetric titration to determine trace moisture, crucial for controlling stability-related effects. |
| Melting Point | Melting Point Apparatus Measurement | Determined using a digital melting point apparatus. The literature melting range is approximately 98–101 °C. Used for preliminary identification and purity assessment; impurities typically cause a lowered or broadened melting point range. |
| Volatile Organic Impurities | Gas Chromatography (GC) | Uses capillary columns (e.g., DB-624) and FID detection to analyze residual solvents (e.g., methanol, acetonitrile, DMF), complying with ICH Q3C guidelines. |
| Cyanide Group Verification | Hydrolysis-Titration Method / Fourier Transform Infrared Spectroscopy (FTIR) | After hydrolysis, ammonia and carboxylic acid are generated; cyanide content is indirectly determined by acid-base titration. Alternatively, FTIR is used to qualitatively and quantitatively confirm the structure based on the characteristic –C≡N absorption peak at ~2240 cm⁻¹. |
| UV Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Solution prepared in ethanol or methanol; absorbance spectrum measured in the 200–300 nm range. Characteristic absorption peaks observed at approximately 225 nm and 270 nm, used for identification and rapid concentration estimation. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, lead, cadmium, mercury, arsenic, and other heavy metals are detected using AAS or ICP-MS. Results must comply with pharmacopoeial limits (e.g., USP/EP), typically ≤10 ppm. |
| Appearance and Color | Visual Inspection + Colorimetry | Inspection of solid form (white to off-white crystalline powder); colorimetric analysis using a colorimeter to measure yellow index (YI) or L*a*b* values, ensuring no noticeable discoloration or contamination. |
Technical Specifications of 4-Cyanopyridine
| Test Item | Specification |
|---|---|
| Appearance | White to almost white crystalline powder |
| Purity | >=98.5% (by LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 134–137°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Identification (NMR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Cyanopyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Cyanopyridine
Packaging of 4-Cyanopyridine
Industrial 4-Cyanopyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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