2-Bromo-4-fluoroaniline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1003-98-1 |
| Product name | 2-Bromo-4-fluoroaniline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Bromo-4-fluoroaniline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Bromo-4-fluoroaniline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Bromo-4-fluoroaniline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing antitumor agents (e.g., BRAF inhibitors) | Diazotization followed by bromination/fluorination; palladium-catalyzed cross-coupling reactions |
| Agrochemicals | Structural building block for synthesizing novel fluorinated aniline-based herbicides and fungicides | Nitration–reduction–halogenation; nucleophilic substitution reactions |
| Materials | Used to prepare high-performance liquid crystal monomers and organic electroluminescent (OLED) materials | Ullmann condensation, Suzuki coupling, and other methods to construct biphenyl or heterocyclic structures |
| Dyes | Diazonium component for synthesizing light- and heat-stable azo dyes | Diazotization followed by coupling with coupling components to form azo pigments |
Manufacturing Quality Control of 2-Bromo-4-fluoroaniline
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance and Physical State | Visual inspection + Physical property testing | Observe sample color and state (typically white to light yellow crystals or powder), determine melting point range (literature value ~58–62°C), and confirm absence of mechanical impurities. |
| Assay (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column, with methanol-water or acetonitrile-buffer salt as the mobile phase. Detect using a UV detector at 254 nm. Quantify using external or internal standard method, ensuring main component purity ≥98%. |
| Impurity Profile Analysis | HPLC-UV / HPLC-MS | Use gradient elution to separate possible impurities (e.g., unreacted starting materials, dehalogenation byproducts, oxidation products). Identify impurities via retention time comparison and mass spectrometry (e.g., 2,4-dibromoaniline, 4-fluoroaniline). Limit single impurity ≤0.5%, total impurities ≤1.0%. |
| Bromine Content Determination | Combustion-Ion Chromatography / Bomb Combustion + Ion-Selective Electrode | Sample is combusted in a bomb to convert bromine into bromide ions. Determine Br⁻ concentration via ion chromatography or bromide ion-selective electrode. Confirm bromine content matches theoretical value (theoretical Br: 47.2%). |
| Fluorine Content Determination | Fluoride Ion-Selective Electrode / Combustion-Ion Chromatography | Release F⁻ via high-temperature hydrolysis or bomb combustion. Quantify using fluoride ion-selective electrode or ion chromatography. Confirm fluorine content matches theoretical value (theoretical F: 9.5%). |
| Water Content | Karl Fischer Titration | Use coulometric or volumetric method to determine trace moisture content. Limit water content ≤0.5% to avoid affecting stability and subsequent reactions. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with a polar column such as DB-624 to detect residual solvents (e.g., methanol, ethanol, ethyl acetate, DMF), in compliance with ICH Q3C limits. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determine lead, cadmium, mercury, arsenic, etc. Limit total heavy metals ≤10 ppm (meets pharmaceutical grade standards). |
| Melting Point | Capillary Melting Point Apparatus | Precisely determine the melting point range and compare with literature values (58–62°C) to assess crystal form purity and presence of eutectic impurities. |
| UV Spectral Characteristics | UV-Visible Spectrophotometer (UV-Vis) | Prepare solution in ethanol or methanol and measure absorption between 200–400 nm (typical λmax ~270–290 nm), for identification and rapid purity screening. |
| Chloride/Sulfate Impurities | Colorimetric Method (Pharmacopoeia Method) | Refer to general chapters of the Chinese Pharmacopoeia. Compare with standard chloride/sulfate solutions by colorimetry, limit chloride ≤0.01%, suitable for preliminary control of active pharmaceutical ingredients. |
Technical Specifications of 2-Bromo-4-fluoroaniline
| Test Item | Specification |
|---|---|
| Appearance | White to light brown crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 35.0–39.0°C |
| Identification (NMR) | Conforms to reference standard |
| Identification (IR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Bromo-4-fluoroaniline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Bromo-4-fluoroaniline
Packaging of 2-Bromo-4-fluoroaniline
Industrial 2-Bromo-4-fluoroaniline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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