8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 100331-89-3 |
| Product name | 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing antitumor and antibacterial quinoline derivatives | Used as a key intermediate in coupling or cyclization reactions to construct novel quinoline scaffold compounds |
| Organic Synthesis | Intermediate for heterocyclic compound synthesis | Applied in preparing quinoline-based functional molecules bearing bromoacetyl and benzyloxy substituents, typically undergoing further transformation via nucleophilic substitution or palladium-catalyzed cross-coupling reactions |
Manufacturing Quality Control of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual inspection, melting point determination | Observe color and crystalline state of the solid; determine melting range using capillary method (typically 120–140°C) to assess conformity with expected physical properties and provide a preliminary evaluation of purity. |
| Identification Test | Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (¹H NMR, ¹³C NMR) | FT-IR detects characteristic functional group absorption peaks (e.g., C=O stretching vibration ~1680 cm⁻¹, phenolic OH ~3200 cm⁻¹, C–Br ~500 cm⁻¹); NMR confirms structures of phenoxy, bromoacetyl, and quinoline rings based on chemical shifts and coupling constants. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with UV detection (λ = 254–280 nm), gradient elution with acetonitrile-water (containing 0.1% formic acid) as mobile phase; quantify main component by external standard method to ensure ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC (gradient elution) | Same system as assay, with extended run time to detect potential degradation products (e.g., debrominated, hydrolyzed, or oxidized impurities). Quantify using reference impurity standards or relative response factors; total impurities ≤2.0%. |
| Residual Solvents | Gas Chromatography with Flame Ionization Detection (GC-FID) | According to ICH Q3C guidelines, test for residual solvents commonly used in synthesis (e.g., ethanol, acetonitrile, dichloromethane, toluene) via headspace or direct injection, using internal standard method to ensure compliance with permitted limits. |
| Water Content | Karl Fischer Titration | Determine trace moisture content using coulometric or volumetric Karl Fischer titration; control water content ≤0.5% to prevent hydrolysis or changes in crystal form that may affect stability. |
| Heavy Metals and Inorganic Impurities | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Test for toxic metal residues such as lead, cadmium, mercury, and arsenic, especially catalysts possibly introduced during synthesis (e.g., Pd, Cu); comply with ICH Q3D limits (e.g., Pb ≤10 ppm). |
| Bromine Content Verification | Combustion-Ion Chromatography (CIC) or X-ray Fluorescence (XRF) | Convert organic bromine to bromide ions via high-temperature combustion followed by ion chromatographic quantification, or use non-destructive XRF to verify presence and proportion of bromine atom in molecule (theoretical Br content ≈22.1%). |
| Crystal Form Analysis | X-ray Powder Diffraction (PXRD) | If polymorphic, confirm consistency of crystal form using PXRD patterns to avoid variations in dissolution rate or stability due to different polymorphs. |
| Solubility and pH | Shake-flask method + pH meter | Determine solubility in buffer solutions across various pH values (e.g., pH 1.2–7.4) to evaluate physicochemical properties for formulation development; pH measurement helps assess molecular acidity/basicity (phenolic OH pKa ≈9–10). |
Technical Specifications of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
Safety Information of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
Industrial 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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