1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1003846-21-6 |
| Product name | 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1003846-21-6
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1003846-21-6 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1003846-21-6
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Synthesis of active pharmaceutical ingredients (APIs) and pharmaceutical intermediates | Serves as a key synthetic building block in Suzuki cross-coupling reactions to construct biologically active molecular frameworks containing pyrazole rings (e.g., JAK inhibitors). |
| Organic Synthesis | Organic synthesis reagent | Enables carbon–carbon bond formation via transition-metal-catalyzed (e.g., palladium-catalyzed) cross-coupling with aryl halides, leveraging the reactivity of the boronate ester group. |
| Scientific Research | New drug discovery and screening | Used to construct compound libraries for high-throughput screening to evaluate biological activity and pharmacological properties in medicinal chemistry. |
Manufacturing Quality Control of 1003846-21-6
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main compound using reversed-phase chromatography with UV detection at 210-254 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., hydrolysis products, regioisomers) using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents (e.g., THF, toluene, ethyl acetate) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Heavy Metals | ICP-MS | Measures trace metal contaminants (e.g., Pd, Ni, Fe) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Content | Ion Chromatography | Quantifies chloride ions using suppressed conductivity detection after aqueous extraction and anion exchange separation. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by high-temperature incineration followed by precise weighing of residual residue. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid using calibrated capillary tube method per USP <741>. |
| Optical Rotation | Polarimetry | Measures specific rotation at sodium D-line to confirm chiral integrity and detect racemization. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size distribution using Mie scattering theory and automated dispersion. |
| Bulk Density | ASTM D1895 Method A | Determines mass per unit volume of freely settled powder using standardized cylinder and tapping procedure. |
| Microbial Limits | Membrane Filtration | Detects aerobic microorganisms and absence of specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of 1003846-21-6
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1003846-21-6
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1003846-21-6
Packaging of 1003846-21-6
Industrial 1003846-21-6 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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