2-Bromo-4-fluorobenzoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1006-41-3 |
| Product name | 2-Bromo-4-fluorobenzoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Bromo-4-fluorobenzoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Bromo-4-fluorobenzoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Bromo-4-fluorobenzoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of pharmaceutical intermediates | Used as a fluorinated aromatic carboxylic acid derivative to construct benzoic acid-based drug scaffolds, serving as a synthetic intermediate for anti-inflammatory agents, antineoplastic agents, or central nervous system drugs |
| Pesticides | Synthesis of fluorinated pesticide intermediates | Applied in the synthesis of biologically active fluorinated benzoic acid-based herbicides, fungicides, or insecticides, with the fluorophenyl group introduced via amidation, esterification, or coupling reactions |
| Chemicals | Organic synthesis building block | Employed as a versatile aromatic compound in Suzuki coupling, Ullmann coupling, and nucleophilic substitution reactions to construct complex aromatic systems |
| Materials Science | Synthesis of functional material monomers | Utilized in the preparation of fluorinated polymers or liquid crystal materials, where the carboxyl functional group participates in condensation or grafting reactions to enhance thermal stability and hydrophobicity |
Manufacturing Quality Control of 2-Bromo-4-fluorobenzoic acid
| Test Item | Common Test Method | Method Summary |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Measure the infrared absorption spectrum of the sample and compare it with the reference spectrum to confirm the presence of characteristic functional groups of 2-bromo-4-fluorobenzoic acid, such as carboxyl group, aromatic ring, C–Br, and C–F bonds. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with methanol/water or acetonitrile/water as the mobile phase, and detect with a UV detector (typically around 254 nm). Determine the content of the main component using external or internal standard method to evaluate purity. |
| Related Substances (Impurity Profiling) | High-Performance Liquid Chromatography (HPLC) | Employ gradient or isocratic elution to separate and detect potential organic impurities (e.g., unreacted starting materials, by-products, degradation products). Impurity levels are calculated using area normalization or a main-component self-dilution method with correction factors. |
| Residual Solvents | Gas Chromatography (GC) | Using headspace or direct injection, analyze residual organic solvents (e.g., toluene, dichloromethane, ethanol) possibly remaining from synthesis on polar or non-polar capillary columns with an FID detector, in accordance with pharmacopoeial standards or ICH guidelines. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Loss on Drying at Atmospheric Pressure | Dry the sample to constant weight at a specified temperature (e.g., 105°C), and determine the percentage loss in mass due to moisture or other volatile components to assess drying stability. |
| Melting Point | Capillary Melting Point Determination | Use a melting point apparatus to measure the temperature range from initial melting to complete melting. Compare with literature values (approximately 197–199°C) as an auxiliary indicator of purity and crystalline form. |
| pH (if prepared as a solution) | pH Meter Method | Dissolve the sample in water or a water-ethanol mixture at a defined concentration and measure its acidity or alkalinity using a calibrated pH meter to reflect the ionization characteristics of the carboxylic acid group. |
| Elemental Impurities (e.g., Br, F) | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Ion Chromatography (IC) | Quantify specific elements (e.g., bromine, fluorine) using ICP-MS for total bromine content or ion chromatography for free fluoride ions, ensuring compliance with elemental impurity control requirements (e.g., ICH Q3D). |
Technical Specifications of 2-Bromo-4-fluorobenzoic acid
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 148–152°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Bromo-4-fluorobenzoic acid
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| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Bromo-4-fluorobenzoic acid
Packaging of 2-Bromo-4-fluorobenzoic acid
Industrial 2-Bromo-4-fluorobenzoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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