1-Boc-3-hydroxy-3-(aminomethyl)azetidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1008526-71-3 |
| Product name | 1-Boc-3-hydroxy-3-(aminomethyl)azetidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-3-hydroxy-3-(aminomethyl)azetidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Synthesis of peptide-based drug intermediates | Used as a protected derivative of azetidine-containing amino acids to construct peptide compounds featuring azetidine rings |
| Organic Synthesis | Advanced organic synthesis intermediate | Deprotected to yield 3-(aminomethyl)-3-hydroxyazetidine, which serves as a building block for complex molecular frameworks |
| Biopharmaceuticals | Synthesis of antitumor and antiviral agents | Applied as a key chiral intermediate in constructing the azetidine moiety of targeted drug molecules |
| Chemical Pharmaceuticals | Synthesis of antibody–drug conjugates (ADCs) | Employed to form stable linker structures connecting antibodies and small-molecule payloads, enhancing drug selectivity and stability |
| Fine Chemicals | Chiral catalyst precursor | Processed via derivatization to serve as chiral ligands or catalyst precursors for asymmetric synthesis reactions |
Manufacturing Quality Control of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to calibrated standard. |
| Related Substances | HPLC-UV | Detects and quantifies impurities by gradient HPLC-UV, with identification via retention time matching and threshold-based reporting. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., THF, EtOAc, MeOH) using gas chromatography with flame ionization detection against certified standards. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Optical Rotation | [alpha]D Measurement | Measures specific rotation using sodium D-line light source to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Fe) at sub-ppb levels using inductively coupled plasma mass spectrometry. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residual Palladium | ICP-OES | Determines palladium residue from catalytic hydrogenation steps using inductively coupled plasma optical emission spectroscopy. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of solid sample against defined reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Loss on Drying | Gravimetric Heating | Measures weight loss after drying under vacuum at 50 C for 2 hours to determine volatile content. |
| pH of Aqueous Suspension | pH Meter | Measures pH of 1% w/v suspension in purified water using calibrated pH electrode per EP 2.2.3. |
Technical Specifications of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128°C - 132°C |
| Optical Rotation | -15.0° to -19.0° (c=1, in methanol) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
Safety Information of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-Boc-3-hydroxy-3-(aminomethyl)azetidine
Industrial 1-Boc-3-hydroxy-3-(aminomethyl)azetidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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