(S)-1-CBZ-3-PYRROLIDINOL 95 Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 100858-32-0 |
| Product name | (S)-1-CBZ-3-PYRROLIDINOL 95 |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for (S)-1-CBZ-3-PYRROLIDINOL 95
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-1-CBZ-3-PYRROLIDINOL 95 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-1-CBZ-3-PYRROLIDINOL 95
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing antiviral agents (e.g., HIV protease inhibitors) and neuroactive drugs | Hydroxyl protection/deprotection step in chiral resolution or asymmetric synthesis; the CBZ group protects the nitrogen atom to facilitate subsequent functional group transformations |
| Pharmaceuticals | Construction of targeted small-molecule inhibitors containing a 3-hydroxypyrrolidine motif (e.g., analogues of DPP-4 inhibitors) | Serves as a key chiral building block in coupling reactions (e.g., Mitsunobu reaction, nucleophilic substitution following sulfonylation/halogenation) or as a cyclization precursor |
| Fine Chemicals | Precursor for synthesizing chiral catalyst ligands | Derivatized to prepare pyrrolidine-based chiral phosphine or amino alcohol ligands, used in asymmetric hydrogenation, epoxidation, and other catalytic reactions |
Manufacturing Quality Control of (S)-1-CBZ-3-PYRROLIDINOL 95
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-230 nm. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess determination using a chiral stationary phase with UV detection, resolving (S)-enantiomer from potential (R)-impurity. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., methanol, ethyl acetate, toluene) via gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in a pyridine-methanol-sulfur dioxide medium. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, using inductively coupled plasma mass spectrometry for sub-pptr detection. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anion on an anion-exchange column with suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Residue mass measurement after controlled high-temperature incineration (500-600 C) following sulfuric acid treatment. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a polarimeter at 20 C with sodium D-line (589 nm) light, indicating chiral integrity. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., deprotected amine, epimer, hydrolysis products) by gradient reversed-phase HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change under controlled heating rate (1-2 C/min). |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against defined standards under controlled lighting and white background. |
| pH of Solution | Potentiometric pH Measurement | Hydrogen ion activity measurement in aqueous suspension or solution using calibrated glass electrode and pH meter. |
Technical Specifications of (S)-1-CBZ-3-PYRROLIDINOL 95
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Optical Rotation | +21.0° to +25.0° (c=1, in CHCl3) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 72°C to 76°C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of (S)-1-CBZ-3-PYRROLIDINOL 95
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-1-CBZ-3-PYRROLIDINOL 95
Packaging of (S)-1-CBZ-3-PYRROLIDINOL 95
Industrial (S)-1-CBZ-3-PYRROLIDINOL 95 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply