R-1-CBZ-3-Hydroxy-piperidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 100858-34-2 |
| Product name | R-1-CBZ-3-Hydroxy-piperidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for R-1-CBZ-3-Hydroxy-piperidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk R-1-CBZ-3-Hydroxy-piperidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of R-1-CBZ-3-Hydroxy-piperidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing active pharmaceutical ingredients (APIs) containing piperidine structures, such as antidepressants and antipsychotics | Used as chiral building blocks in multi-step organic synthesis—including coupling, reduction, and protection/deprotection—to construct chiral centers |
| Pharmaceutical R&D | Chiral auxiliaries or ligand precursors in asymmetric synthesis | Derivatized for use as chiral ligands in metal-catalyzed reactions (e.g., with palladium or rhodium) to control stereoselectivity |
Manufacturing Quality Control of R-1-CBZ-3-Hydroxy-piperidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210-230 nm based on peak area comparison to reference standard. |
| Chiral Purity | Chiral HPLC | Measures enantiomeric excess by separation on a chiral stationary phase and UV detection, comparing retention times and peak areas of (S)- and (R)-enantiomers. |
| Residual Solvents | GC-FID | Identifies and quantifies volatile organic solvents (e.g., methanol, ethyl acetate) using gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration using iodine-based reagent where water reacts stoichiometrically with iodine and sulfur dioxide. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, As) after acid digestion via inductively coupled plasma mass spectrometry with isotope-specific detection. |
| Residual Palladium | ICP-OES | Measures palladium content from catalytic hydrogenation residues using inductively coupled plasma optical emission spectroscopy at characteristic wavelengths. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after anion-exchange column separation. |
| Sulfate Impurity | Ion Chromatography | Quantifies sulfate ions via anion-exchange chromatography with conductivity detection using sodium carbonate/bicarbonate eluent. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., deprotected, oxidized, or dimeric species) using gradient reverse-phase HPLC with UV detection. |
| Optical Rotation | [alpha]D Measurement | Determines specific optical rotation using a digital polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity and identity. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range over which solid transitions to liquid, indicating purity and identity via comparison to literature value. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of solid sample against defined standards under controlled white light and against white/black backgrounds. |
Technical Specifications of R-1-CBZ-3-Hydroxy-piperidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128-132°C |
| Optical Rotation | +28.0 to +32.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of R-1-CBZ-3-Hydroxy-piperidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of R-1-CBZ-3-Hydroxy-piperidine
Packaging of R-1-CBZ-3-Hydroxy-piperidine
Industrial R-1-CBZ-3-Hydroxy-piperidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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