(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 1012341-50-2 |
| Product name | (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 1012341-50-2
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1012341-50-2 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1012341-50-2
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a chiral intermediate in the synthesis of anti-inflammatory drugs | Chemical synthesis via chiral resolution or asymmetric catalytic reactions |
| Chemical Feedstocks | Employed as an amino-protecting group in organic synthesis reactions | Introduction of the tert-butoxycarbonyl (Boc) protecting group via esterification |
| Pharmaceutical Manufacturing | Synthesis of biologically active peptides or small-molecule drugs | Solid-phase or liquid-phase synthesis, combined with multi-step organic reactions |
Manufacturing Quality Control of 1012341-50-2
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Chemical Purity | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 column with gradient elution of phosphate buffer/acetonitrile or methanol as mobile phase. The UV detector (e.g., 210–220 nm) quantifies the main peak area to assess total impurities and purity of the main component. |
| Enantiomeric Purity / Optical Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Uses chiral stationary phase columns (e.g., CHIRALPAK® series) to separate the target (2R,4S) isomer from its enantiomer, and calculates enantiomeric excess (ee%). |
| Residual Solvents | Gas Chromatography (GC), Headspace Injection | According to ICH Q3C, residual organic solvents (e.g., methanol, ethyl acetate, DMF) are determined using a capillary column (e.g., DB-624) with FID or MS detection and automated headspace sampling. |
| Loss on Drying | Drying Method / Karl Fischer Moisture Titration | Drying method: measures volatile content by constant weight at 105°C; Karl Fischer method: titration for precise determination of water content in the sample. |
| Sulfated Ash / Residue on Ignition | Gravimetric Analysis | Sample is ignited at high temperature (700–800°C), and the residue of inorganic matter is weighed to evaluate inorganic impurity content. |
| Heavy Metals | ICP-MS or Atomic Absorption Spectroscopy (AAS) | After acid digestion of the sample, ICP-MS or AAS is used to determine residual heavy metal elements such as lead, cadmium, mercury, and arsenic, in compliance with ICH Q3D limits. |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS) | ¹H-NMR and ¹³C-NMR confirm molecular structure and stereochemistry; high-resolution mass spectrometry (HRMS) verifies molecular weight and fragment ions to ensure correct compound identity. |
| Related Substances (Impurity Profile) | HPLC-UV / LC-MS | Optimized gradient elution separates and identifies process-related impurities and degradation products; LC-MS assists in structural elucidation, establishing an impurity profile compliant with ICH Q3A/B requirements. |
| Specific Optical Rotation | Polarimetry | A solution of defined concentration is prepared, and optical rotation is measured at a specified wavelength (typically 589 nm, sodium D-line). Specific rotation [α] is calculated to verify consistency of stereochemical configuration. |
| pH Value (if in liquid formulation) | pH Meter Measurement | For injectable or oral liquid formulations, pH must be controlled within a specified range to ensure stability and safety. |
Technical Specifications of 1012341-50-2
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Optical Rotation | +18.5 to +20.5° (c=1, in CHCl3) |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 1012341-50-2
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1012341-50-2
Packaging of 1012341-50-2
Industrial 1012341-50-2 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply