FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1013883-02-7 |
| Product name | FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | As a protecting amino acid derivative in peptide synthesis, for solid-phase or solution-phase peptide chain elongation | Participates in peptide bond formation under the Fmoc/tBu strategy, enabling selective coupling via deprotection steps |
| Pharmaceutical R&D | For constructing tyrosine-containing targeted peptides or protein drug precursors | Employed in standard solid-phase peptide synthesis (SPPS), with stepwise peptide chain assembly on resin |
| Chemical Research | As a synthetic intermediate for fluorescently labeled or multifunctionally modified peptides | Utilizes orthogonal Fmoc and Boc protecting groups to enable sequential deprotection and coupling reactions |
Manufacturing Quality Control of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Melting Point Determination | Observe the sample as a white to off-white crystalline powder; determine the melting point range (typically 105–115°C), and compare with reference standard to assess purity and crystalline state. |
| Identification | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with water-acetonitrile gradient elution, UV detection at 254 nm (Fmoc absorption peak); compare retention time with that of reference standard to confirm identity of the main component. |
| Fourier Transform Infrared Spectroscopy (FT-IR) | Compare characteristic functional group absorption peaks (e.g., carbonyl of Fmoc at ~1730 cm⁻¹, carbonyl of Boc at ~1690 cm⁻¹, N-H stretch of amine at ~3300 cm⁻¹) with reference spectrum to verify structural integrity. | |
| Nuclear Magnetic Resonance (¹H NMR / ¹³C NMR) | Measure in DMSO-d₆ or CDCl₃ solvent; analyze aromatic protons (Fmoc), tertiary butyl protons (Boc), methylene protons, and tyrosine phenyl signals to confirm molecular structure and substitution positions. | |
| Content Determination (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution (water/acetonitrile, containing 0.1% TFA), UV detection at 254 nm; calculate main peak purity by area normalization method, typically requiring ≥98.0%. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection with capillary columns such as DB-624; detect common synthesis solvents like acetonitrile, dichloromethane, methanol, ethyl acetate; ensure compliance with ICH Q3C limits. |
| Water Content | Karl Fischer Titration (Coulometric or Volumetric) | Determine moisture content using coulometric or volumetric Karl Fischer method; typically require ≤1.0% to ensure stability and proper storage conditions. |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution with sensitivity set to detect impurities at 0.1% level relative to the main peak; identify degradation products (e.g., de-Boc, de-Fmoc, hydrolysis products, oxidation products); individual impurity ≤0.5%, total impurities ≤1.0%. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine levels of lead, cadmium, mercury, arsenic according to pharmacopoeial methods (e.g., USP <231> or EP 2.4.8); control within ≤10 ppm. |
| Inorganic Impurities (e.g., Chloride, Sulfate) | Ion Chromatography or Colorimetric Methods | Detect chloride and sulfate ions via ion chromatography or classical colorimetric methods (e.g., silver nitrate titration for chloride); ensure concentrations are within pharmacopoeial specifications. |
| Solubility | Solubility Testing | Determine solubility behavior in common solvents such as water, ethanol, DMF, DMSO—used for formulation process reference; typical profile: slightly soluble in water, freely soluble in DMF/DMSO. |
| Specific Rotation | Polarimeter Measurement | Prepare a solution of specified concentration (e.g., 1%) in DMF or methanol; measure specific rotation at 20°C under sodium D-line; compare with literature values (e.g., [α]D²⁰ ≈ +10° to +15°) to confirm correct stereochemistry. |
| Thermal Stability (TGA/DSC) | Thermogravimetric Analysis (TGA) / Differential Scanning Calorimetry (DSC) | Analyze thermal decomposition temperature and endothermic melting peak to evaluate thermal stability; confirm absence of hydrates or solvent complexes; assist in assessing polymorphic consistency. |
Technical Specifications of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | -25.0 to -29.0° (c=1, DMF) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
Safety Information of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE
Industrial FMOC-4-[2-(BOC-AMINO)ETHOXY]-L-PHENYLALANINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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