N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 101469-92-5 |
| Product name | N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing antiviral agents (e.g., HIV protease inhibitors) and anticancer drugs | Introduction and removal of hydroxyl protecting groups in asymmetric synthesis, chiral resolution, or chiral pool synthesis |
| Pharmaceutical R&D | Construction of chiral pyrrolidine-containing candidate drug molecules for structure–activity relationship (SAR) studies | Key chiral building block in multistep organic synthesis, participating in coupling, cyclization, and functional group transformations |
| Fine Chemicals | Precursor to chiral catalyst ligands or chiral auxiliaries | Derivatized to prepare chiral phosphine ligands, amino alcohol ligands, or N-heterocyclic carbene precursors |
Manufacturing Quality Control of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separates (S)- and (R)-enantiomers on a chiral stationary phase and calculates ee from peak area ratio. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., THF, EtOAc, MeOH) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Measures water by coulometric or volumetric titration using iodine generation and stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantifies trace metals (e.g., Pb, Cd, Ni, Fe) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column and conductivity detection. |
| Residual Boc Protecting Group | HPLC-UV | Detects residual di-tert-butyl dicarbonate (Boc2O) or tert-butanol by reverse-phase HPLC with UV detection. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., deprotected pyrrolidine, oxidation products) using gradient HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity. |
| Optical Rotation | [alpha]D Measurement | Measures specific rotation at 589 nm using sodium D-line to confirm chiral integrity and concentration. |
| pH of Aqueous Suspension | pH Meter | Evaluates acidity/basicity by measuring pH of a standardized suspension in water or water/isopropanol. |
| Particle Size Distribution | Laser Diffraction | Determines size distribution of solid particles in suspension using angular scattering intensity of laser light. |
Technical Specifications of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | +25.0 to +29.0° (c=1, in CHCl3) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 68 to 72°C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
Safety Information of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol
Industrial N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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