6-Chloro-1H-pyrazolo[4,3-c]pyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1206979-33-0 |
| Product name | 6-Chloro-1H-pyrazolo[4,3-c]pyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-Chloro-1H-pyrazolo[4,3-c]pyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-Chloro-1H-pyrazolo[4,3-c]pyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for novel insecticides, used in synthesizing pyrazolopyrimidine compounds exhibiting nicotinic acetylcholine receptor (nAChR) agonist activity | Undergoes substitution with amines (e.g., 3-chloro-5-(trifluoromethyl)pyridin-2-amine), followed by cyclization and oxidation to construct the target bioactive molecule |
| Pharmaceuticals | Key structural motif in kinase inhibitor candidates, employed in the development of inhibitors targeting JAK2, FLT3, and other kinases | Serves as a heterocyclic building block in cross-coupling reactions—including Suzuki coupling and Buchwald–Hartwig amination—to introduce specific substituents that optimize pharmacological activity and ADME properties |
Manufacturing Quality Control of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances (Impurities) | HPLC-UV or UPLC-UV | Separation and quantification of structurally related impurities (e.g., des-chloro analog, regioisomers, hydrolysis products) using gradient elution and UV detection. |
| Residual Solvents | GC-FID or GC-MS | Headspace gas chromatography with flame ionization detection (or mass spectrometry) to quantify residual solvents (e.g., DMF, dichloromethane, methanol) per ICH Q3C guidelines. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic elements (e.g., Pb, Cd, Hg, As) after acid digestion, achieving sub-ppb sensitivity and compliance with ICH Q3D. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration using iodine generated in situ to determine trace water content based on stoichiometric reaction with Karl Fischer reagent. |
| Chloride Content | Ion Chromatography (IC) or Potentiometric Titration | Quantitative determination of inorganic chloride ions (e.g., from hydrochloride salt or residual HCl) via suppressed conductivity detection (IC) or silver nitrate titration with endpoint detection. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using Mie scattering theory to determine D10, D50, D90 values per USP <429>. |
| Melting Point | Digital Melting Point Apparatus | Thermal analysis by capillary method to determine onset and range of solid–liquid phase transition, verifying identity and crystallinity. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after controlled high-temperature ashing (600–750 °C), indicating non-volatile inorganic impurities. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm chiral purity (if applicable) and detect racemization or enantiomeric impurities. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined suspension (e.g., 1% w/v in water) to assess acidic/basic degradation or residual catalysts. |
| Microbial Limits | Membrane Filtration & Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 178–182 °C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
Safety Information of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
Industrial 6-Chloro-1H-pyrazolo[4,3-c]pyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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