5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 121058-82-0 |
| Product name | 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals / Molecular Biology | Protective nucleoside phosphoramidite monomers for oligonucleotide synthesis | Used in solid-phase synthesis (e.g., phosphoramidite triester method) to construct deoxycytidine-containing DNA sequences; the 5′-O-DMT group protects the 5′-hydroxyl, and the N4-acetyl group protects the cytosine base to suppress side reactions and improve coupling efficiency |
Manufacturing Quality Control of 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 260 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities (e.g., deblocked, deacetylated, or hydrolyzed forms) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., dichloromethane, acetonitrile, DMF) based on retention time and flame ionization response. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent to determine trace water content based on stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Multi-element detection and quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion using inductively coupled plasma mass spectrometry. |
| Residual Triphenylmethanol | HPLC-UV | Specific detection and quantification of triphenylmethanol, a common cleavage byproduct, using isocratic HPLC with UV detection. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20 degC with sodium D-line (589 nm) to confirm chiral integrity. |
| pH of Solution | Potentiometric pH Measurement | Measurement of hydrogen ion activity in aqueous solution using calibrated glass electrode and pH meter. |
| Residual Chloride | Ion Chromatography | Separation and conductivity-based quantification of chloride ions after sample dissolution and filtration. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per pharmacopeial methods. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution by measuring angular variation in laser light scattering intensity. |
| Loss on Drying | Gravimetric Analysis | Determination of volatile content by measuring weight loss after controlled heating under defined temperature and vacuum conditions. |
Technical Specifications of 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Optical Rotation | -15.0 to -19.0° (c=1, in CHCl3) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine
Industrial 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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