2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1211443-58-1 |
| Product name | 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1211443-58-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
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Industrial Applications of 1211443-58-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key intermediate for Janus kinase (JAK) inhibitors | Serves as a core building block in the synthesis of JAK inhibitors (e.g., ruxolitinib derivatives), enabling structural modification of the pyrimidine and pyrrole rings to develop active pharmaceutical ingredients for treating myelofibrosis, polycythemia vera, and autoimmune disorders. |
| Pharmaceutical Chemicals | Raw material for chemical API synthesis | Used in C–C or C–N bond-forming reactions during drug synthesis; the carboxylic acid functionality is converted (e.g., via amidation or esterification) to introduce side chains and construct the biologically active final drug molecule. |
| Scientific Research | Tool molecule for drug target studies | Functions as a probe compound to investigate the JAK-STAT signaling pathway and its role in cellular proliferation, differentiation, and immune regulation, supporting lead compound screening and optimization. |
Manufacturing Quality Control of 1211443-58-1
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (HPLC Purity) | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 reversed-phase column with gradient elution using water-acetonitrile or methanol, detected by UV detector (220–280 nm). Main component purity is calculated via area normalization method, capable of detecting impurity peaks, meeting pharmacopoeial or in-house control standards (e.g., ≥98.0%). |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Uses the same HPLC system as purity testing but optimized to separate potential impurities (e.g., dechlorinated products, hydrolysis products, unreacted starting materials, stereoisomers). Combined with mass spectrometry (MS) for structural identification; quantitation limit typically at 0.1%. |
| Content Determination (Main Component Content) | HPLC-UV or Titration Method | HPLC method: Quantified using external standard approach with high-purity reference standard, calculating main component content (on dried basis). Titration method: Suitable for compounds containing carboxylic acid groups, performed via acid-base titration with standardized sodium hydroxide solution (solvent interference such as DMSO or water must be considered). |
| Water Content | Karl Fischer Titration | Based on the quantitative reaction between iodine, sulfur dioxide, pyridine, and methanol with water, measured by electrochemical or volumetric Karl Fischer titration. Applicable to solid active pharmaceutical ingredients, with moisture controlled ≤1.0% (based on stability requirements). |
| Residual Solvents | Gas Chromatography (GC) | Uses headspace or direct injection GC-FID to detect potentially residual organic solvents (e.g., methanol, ethanol, acetonitrile, dichloromethane) according to ICH Q3C guidelines. Quantified using standard calibration curves, controlled within PDE limits. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After acid digestion of samples, lead, cadmium, mercury, arsenic, copper, and other heavy metals are analyzed by AAS or more sensitive ICP-MS, complying with ICH Q3D or pharmacopoeial limits (e.g., Pb ≤ 5 ppm). |
| Melting Point | Melting Point Apparatus Measurement | Determined using capillary method or automated melting point instrument; compared with literature values or reference standard (typical range: approximately 210–220°C, decomposition). Used for preliminary identification and auxiliary assessment of purity. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Characteristics absorption peaks measured in KBr pellet or ATR mode (e.g., carboxyl C=O stretch ~1700 cm⁻¹, aromatic C=C ~1600 cm⁻¹, N-H ~3200 cm⁻¹), used for structural confirmation and comparison with reference standard. |
| Ultraviolet-Visible Absorption Spectroscopy (UV-Vis) | UV-Visible Spectrophotometry | Solution prepared in methanol or acetonitrile; maximum absorption wavelength (λmax, typically 240–270 nm) determined, used for auxiliary identification and quantification (if method is validated). |
| Solubility | Shake Flask Method / Visual Observation | Equilibrium solubility assessed in different pH buffers (e.g., pH 1.2, 4.5, 6.8) and pure water to evaluate feasibility for formulation development. Not a mandatory quality control parameter but provides valuable reference data. |
| Polymorphism (if applicable) | X-Ray Powder Diffraction (XRPD) | If polymorphic risk exists, XRPD is used to analyze solid-state crystal form and compared with standard patterns to ensure batch-to-batch consistency. |
| Particle Size Distribution (if applicable for formulations) | Laser Diffraction Method | If used in oral solid dosage forms, particle size distribution (D10, D50, D90) must be evaluated, as it affects dissolution rate and flowability. |
Technical Specifications of 1211443-58-1
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=99.0% (LC-MS) |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 248–252°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Industrial 1211443-58-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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