China Factory Direct
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| CAS number | 1222-98-6 |
| Product name | 4-NITROCHALCONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeReagent GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Serving as a synthetic intermediate in research on anti-inflammatory, anticancer, and antimicrobial agents | Used to construct heterocyclic compound scaffolds via Michael addition or cyclization reactions |
| Organic Synthesis | Employed to build chalcone derivative libraries for screening biologically active molecules | Prepared from aromatic aldehydes and nitroacetophenones via Claisen-Schmidt condensation |
| Materials Science | Applied as a precursor for nonlinear optical materials | Processed into functional crystals or polymeric materials via crystallization or polymerization |
| Analytical Chemistry | Utilized as a spectroscopic reagent or in the development of fluorescent probes | Molecular design leverages its conjugated structure and the electronic properties of the nitro group |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies 4-nitrochalcone by separation on a reversed-phase column and UV detection at ~350 nm, comparing peak area to a calibrated standard. |
| Related Substances | HPLC-DAD | Detects and quantifies structurally similar impurities (e.g., unreacted aldehydes, ketones, or reduction/by-product peaks) using diode-array detection for spectral confirmation. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents (e.g., ethanol, acetone, DMF) by gas chromatography with flame ionization detection against reference standards. |
| Moisture Content | Karl Fischer Titration | Determines water content via coulometric or volumetric titration based on the stoichiometric reaction of iodine with water in a pyridine/methanol buffer. |
| Heavy Metals | ICP-OES | Measures trace metal contaminants (e.g., Pb, Cd, Ni, Fe) after acid digestion by detecting element-specific atomic emissions in an inductively coupled plasma. |
| Chloride Impurity | Ion Chromatography | Quantifies chloride ions using suppressed conductivity detection after anion exchange separation in aqueous matrix. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity via comparison to literature value (~127-129 C). |
| Organic Volatile Impurities (OVI) | GC-MS | Identifies and quantifies unknown or low-level volatile impurities using mass spectral library matching and selected ion monitoring. |
| Loss on Drying (LOD) | Gravimetric Heating | Measures weight loss after drying under controlled temperature/vacuum, reflecting volatile content including residual solvents and moisture. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution detects free carboxylic acids (if present as degradation products) using phenolphthalein endpoint. |
| Sulfated Ash | Gravimetric Incineration | Measures inorganic residue after high-temperature incineration in presence of sulfuric acid, indicating total inorganic impurities. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size via scattering pattern of laser beam, reporting D10/D50/D90 values relevant for handling and formulation. |
| Test Item | Specification |
|---|---|
| Appearance | Yellow crystalline solid |
| Purity | >=98.5% (GC-MS) |
| Melting Point | 104–108°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.