(S)-3-Hydroxypyrrolidine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 122536-94-1 |
| Product name | (S)-3-Hydroxypyrrolidine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-3-Hydroxypyrrolidine hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-3-Hydroxypyrrolidine hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-3-Hydroxypyrrolidine hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing antiviral agents (e.g., HCV NS5A inhibitors) and neurokinin-1 (NK1) receptor antagonists | Purified via hydrochloride salt formation following asymmetric synthesis or chiral resolution |
| Pharmaceuticals | Chiral building block for constructing pyrrolidine-containing drug scaffolds to enhance potency and metabolic stability | Used as a chiral auxiliary in cyclization, substitution, or coupling reactions (e.g., as a precursor for Suzuki coupling) |
| Fine Chemicals | Structural unit for chiral catalyst ligands, particularly chiral phosphine–nitrogen hybrid ligands | Coordinated to metal centers after protection or functional group modification, for asymmetric hydrogenation or C–N coupling |
Manufacturing Quality Control of (S)-3-Hydroxypyrrolidine hydrochloride
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and physical state (e.g., white to off-white powder), and check for clumping or visible impurities. |
| Identification | Infrared Spectroscopy (IR) | Compare the sample's spectrum with a reference standard to confirm molecular structure consistency by analyzing characteristic absorption peaks (e.g., O-H, N-H, C-O). |
| Proton Nuclear Magnetic Resonance (¹H-NMR) | Measure the proton spectrum in deuterated solvents, and compare chemical shifts, coupling constants, and integration areas to confirm compound stereochemistry and structure. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a UV detector (typically 210–220 nm) to determine the main component content via external standard or internal standard method. |
| Non-aqueous Titration | Titrate the free base in hydrochloride salts using perchloric acid standard solution in a non-aqueous solvent (e.g., glacial acetic acid) to calculate the active ingredient content. | |
| Chiral Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use a chiral stationary phase column to separate enantiomers and detect the ratio of (S)- and (R)-isomers to evaluate optical purity (enantiomeric excess, e.e.). |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution to separate and detect potential organic impurities (e.g., starting materials, intermediates, degradation products); quantify using peak area normalization or external standard method. |
| Water Content | Karl Fischer Titration | Measure water content using electrochemical titration principles; suitable for solid samples with low moisture content. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Oven Method | Dry the sample at a specified temperature (e.g., 60–105°C) for a defined period and calculate the content of volatile substances based on weight loss. |
| Residue on Ignition (Sulfated Ash) | Sulfation followed by High-Temperature Incineration | Carbonize the sample with sulfuric acid, then incinerate at 500–600°C until constant weight; weigh the residual inorganic material to assess inorganic impurity content. |
| Chloride Ion Test | Ion Chromatography or Silver Nitrate Turbidity Method | Detect excess chloride ions or inorganic chloride impurities in hydrochloride salts to ensure compliance with pharmacopeial limits. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determine concentrations of heavy metal elements (e.g., lead, cadmium, mercury, arsenic) to ensure compliance with ICH or pharmacopeial limits. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH Q3C guidelines, detect organic solvents potentially residual from manufacturing processes (e.g., methanol, ethanol, dichloromethane). |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range using the capillary tube method to assess purity and batch consistency. |
Technical Specifications of (S)-3-Hydroxypyrrolidine hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128-132°C |
| Optical Rotation | +7.0 to +8.5° (c=1, H2O) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-3-Hydroxypyrrolidine hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-3-Hydroxypyrrolidine hydrochloride
Safety Information of (S)-3-Hydroxypyrrolidine hydrochloride
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (S)-3-Hydroxypyrrolidine hydrochloride
Industrial (S)-3-Hydroxypyrrolidine hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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