Fmoc-L-glutamic acid-gamma-benzyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 123639-61-2 |
| Product name | Fmoc-L-glutamic acid-gamma-benzyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-L-glutamic acid-gamma-benzyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-L-glutamic acid-gamma-benzyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-L-glutamic acid-gamma-benzyl ester
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Protecting reagent for the glutamic acid side chain in solid-phase peptide synthesis | Used in Fmoc-based solid-phase peptide synthesis (SPPS) to selectively protect the γ-carboxyl group of L-glutamic acid, preventing side reactions during peptide chain elongation; the Fmoc group protects the α-amino group, while the benzyl ester (OBn) protects the γ-carboxyl group—both groups are orthogonally removable |
| Pharmaceutical R&D | Key building block for synthesizing peptide-based drugs and intermediates | Applied in the synthesis of therapeutic peptides containing glutamic acid residues (e.g., hormone analogs, antimicrobial peptides, targeting peptides), ensuring controlled handling of side-chain functional groups prior to coupling, cyclization, or modification steps |
| Fine Chemicals | Standard starting material for custom synthesis of chiral amino acid derivatives | Enables stepwise deprotection and structural modification via selective removal of the benzyl ester group using palladium-catalyzed hydrogenolysis or a trichloroacetic acid/anisole system, or removal of the Fmoc group using piperidine/DMF |
Manufacturing Quality Control of Fmoc-L-glutamic acid-gamma-benzyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 268 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., Fmoc-Glu-OH, benzyl alcohol, dipeptide by-products) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of volatile solvents (e.g., DMF, DCM, toluene) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in a pyridine-methanol solvent system. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity. |
| Heavy Metals | ICP-MS | Quantitative analysis of elemental impurities (e.g., Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-MS | Specific quantification of Pd from coupling catalyst residues via acid digestion followed by ICP-MS detection. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying under controlled temperature and vacuum to determine volatile and moisture content. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution in suspension using Mie scattering theory and laser diffraction instrumentation. |
| pH of Aqueous Suspension | Potentiometric Titration | Measurement of pH in a defined aqueous suspension (e.g., 1% w/v) using calibrated glass electrode and pH meter. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic microorganisms by filtration, membrane transfer to culture media, and colony counting after incubation. |
Technical Specifications of Fmoc-L-glutamic acid-gamma-benzyl ester
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Optical Rotation | -15.0 to -19.0° (c=1, DMF) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-L-glutamic acid-gamma-benzyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-L-glutamic acid-gamma-benzyl ester
Safety Information of Fmoc-L-glutamic acid-gamma-benzyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-L-glutamic acid-gamma-benzyl ester
Industrial Fmoc-L-glutamic acid-gamma-benzyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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