N-Boc-Piperidine-4-carboxylic acid methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 124443-68-1 |
| Product name | N-Boc-Piperidine-4-carboxylic acid methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Boc-Piperidine-4-carboxylic acid methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Boc-Piperidine-4-carboxylic acid methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Boc-Piperidine-4-carboxylic acid methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a building block for piperidine derivatives; leverages the stability and facile removal of the N-Boc protecting group for scaffold construction and structural modification of drug molecules. |
| Pharmaceutical Chemicals | Synthesis of Specific Active Pharmaceutical Ingredients (APIs) | Applied in the synthesis of novel drug molecules such as protein kinase inhibitors and receptor antagonists (e.g., chemokine receptor antagonists); hydrolysis yields carboxylic acid intermediates, while reduction yields alcohol intermediates. |
| Organic Synthesis | Functional Group Transformation | Enables selective hydrolysis, reduction, or coupling reactions by exploiting the differential reactivity of the ester and N-Boc groups to prepare key intermediates including N-Boc-4-piperidinecarboxylic acid and N-Boc-4-piperidinemethanol. |
Manufacturing Quality Control of N-Boc-Piperidine-4-carboxylic acid methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify residual solvents (e.g., methanol, THF, DMF) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Inductively coupled plasma mass spectrometry for simultaneous quantification of elemental impurities (e.g., Pb, Cd, Ni, As) at sub-ppb levels. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract; quantified against sodium chloride calibration curve. |
| Optical Rotation | [alpha]D Measurement | Polarimetric measurement at 20 C and 589 nm to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change in a capillary tube under controlled heating rate. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue after high-temperature ashing (700-800 C) to assess inorganic non-volatile impurities. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of neat sample against established reference standards under controlled lighting. |
| pH of Aqueous Solution | pH Meter | Measurement of pH in a 1% w/v aqueous suspension using calibrated pH electrode and temperature compensation. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion via laser scattering to determine D10, D50, D90 values per ISO 13320. |
Technical Specifications of N-Boc-Piperidine-4-carboxylic acid methyl ester
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic, mild |
| Optical Rotation | -5.0 to +5.0 deg (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Boc-Piperidine-4-carboxylic acid methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Boc-Piperidine-4-carboxylic acid methyl ester
Safety Information of N-Boc-Piperidine-4-carboxylic acid methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Boc-Piperidine-4-carboxylic acid methyl ester
Industrial N-Boc-Piperidine-4-carboxylic acid methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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