2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 126120-85-2 |
| Product name | 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of antiviral drugs (e.g., sofosbuvir) | Used in constructing nucleoside analogues via organic synthesis steps including esterification and condensation |
| Chemical Synthesis | Building block for fluorinated aromatic carboxylic acid structural units | Introduced into target molecular frameworks via nucleophilic substitution, coupling reactions, or protecting group strategies |
| Drug Discovery | Metabolically stable carboxylic acid moiety employed in prodrug design | Forms hydrolyzable linkages with alcohols or amines during prodrug modification to enhance bioavailability |
Manufacturing Quality Control of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination based on peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at ~220–254 nm. |
| Related Substances | HPLC-UV/DAD or UPLC-MS | Separation and identification/quantification of structurally related impurities (e.g., starting materials, intermediates, degradation products) using gradient elution and diode-array or mass spectrometric detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common organic solvents (e.g., methanol, acetone, ethyl acetate) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based reagent. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic elements (e.g., Pb, Cd, Hg, As) after acid digestion, based on elemental mass-to-charge ratio detection with high sensitivity. |
| Residue on Ignition | Gravimetric Analysis (Sulfated Ash) | Determination of inorganic residue after controlled charring and sulfuric acid treatment followed by high-temperature incineration and weighing. |
| Chloride Impurity | Ion Chromatography (IC) with Conductivity Detection | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Optical Rotation | [α]D | Measurement of specific rotation using a polarimeter at 20 °C with sodium D-line (589 nm) to confirm chiral integrity (if applicable; compound is achiral but method may be specified for batch consistency). |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity via comparison to reference material. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution in dry or dispersed state using Mie scattering theory and angular intensity measurement of diffracted laser light. |
Technical Specifications of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (by LC-MS) |
| Melting Point | 142–146 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
Safety Information of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
Industrial 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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