(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 126330-90-3 |
| Product name | (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing antidepressants, antipsychotics, and dopamine receptor modulators (e.g., paliperidone analogues) | Preparation of target active pharmaceutical ingredients (APIs) via chiral resolution or asymmetric synthesis, followed by salt formation, crystallization purification, and subsequent amide coupling or reductive amination |
| Pharmaceutical R&D | Construction of chiral compound libraries containing piperazine scaffolds for hit identification targeting G protein-coupled receptors (GPCRs) | Solid-phase or solution-phase combinatorial synthesis; incorporation as a C2-symmetric chiral building block into the molecular core structure |
| Fine Chemicals | High-value chiral reagents for synthesizing catalytic ligands (e.g., P,N-bidentate ligands) | Coupling with chiral phosphine or oxazoline functionalities, followed by deprotection and metal complexation to generate asymmetric catalytic precursors |
Manufacturing Quality Control of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess determination using a chiral stationary phase and UV detection, resolving (R)- and (S)-enantiomers. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent to quantify water based on stoichiometric reaction with iodine and sulfur dioxide. |
| Residual Solvents | GC-FID | Separation and quantification of volatile organic solvents (e.g., methanol, acetone, ethyl acetate) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Ni, Fe) after acid digestion, based on atomic emission intensities. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to detect endpoint via potential change in chloride ion precipitation. |
| pH of Aqueous Solution | pH Meter Measurement | Direct measurement of pH in a 1% w/v aqueous solution using a calibrated glass electrode pH meter. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities using gradient HPLC-UV, with identification by retention time relative to reference standards. |
| Loss on Drying | Gravimetric Analysis | Mass loss upon heating at 105 C for 2 hours under controlled humidity, indicating volatile content including residual solvents and moisture. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 C using sodium D-line (589 nm) to confirm chiral identity and enantiomeric integrity. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) after filtration and culture on selective media. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution by measuring angular variation in laser light scattering intensity. |
Technical Specifications of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to pale-yellowish powder |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +5.0±1.0°, c = 1% in H2O |
| Melting Point | 220-225°C (decomposes) |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
Safety Information of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
Industrial (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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