4-Bromo-2-fluoropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 128071-98-7 |
| Product name | 4-Bromo-2-fluoropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Bromo-2-fluoropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Bromo-2-fluoropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Bromo-2-fluoropyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Pharmaceutical Intermediate | Serves as a key building block in Suzuki coupling or Buchwald–Hartwig amination reactions to construct pyridine-containing drug scaffolds (e.g., antitumor and anti-inflammatory agents). |
| Agrochemical Industry | Agrochemical Intermediate | Used in the synthesis of novel pyridine-ring-containing insecticides and herbicides; active functional groups are introduced via bromine substitution to optimize biological activity and selectivity. |
| Organic Synthesis | Synthesis of Fluoropyridine Derivatives | The fluorine atom at the 2-position undergoes nucleophilic substitution (e.g., with amines or alcohols) to prepare a series of 2-substituted pyridine derivatives. |
| Organic Synthesis | Bifunctional Modification Compound | Leverages differential reactivity of the bromine and fluorine atoms to enable sequential, selective functionalization for synthesizing polysubstituted pyridine compounds. |
| Materials Science | Synthesis of Organic Optoelectronic Materials | Employed to construct organic ligands or luminescent material monomers with tailored electronic properties; coupling reactions modulate band structure and optoelectronic performance. |
Manufacturing Quality Control of 4-Bromo-2-fluoropyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, DMF) against calibrated standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generated in situ to react stoichiometrically with water; endpoint detected potentiometrically. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion, using isotopic dilution or external calibration. |
| Chloride Impurity | Ion Chromatography | Separation of chloride anion on an anion-exchange column with suppressed conductivity detection; quantified via external calibration. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after controlled ashing at 600 C in a muffle furnace, followed by weighing. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the solid-to-liquid phase change under controlled heating rate. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of the neat solid against defined standards (e.g., white to off-white crystalline powder). |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through a solution, indicating chiral purity if applicable (though compound is achiral, used for batch consistency). |
| pH of Aqueous Suspension | pH Meter | Determination of surface acidity/basicity by measuring pH of a saturated aqueous suspension (1:10 w/v) using calibrated electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. scattering angle to calculate volume-based particle size distribution in dry or dispersed state. |
Technical Specifications of 4-Bromo-2-fluoropyridine
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.535–1.545 |
| Relative Density (20°C/25°C) | 1.54–1.56 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Bromo-2-fluoropyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Bromo-2-fluoropyridine
Packaging of 4-Bromo-2-fluoropyridine
Industrial 4-Bromo-2-fluoropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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