(2-Hydroxypropyl)-γ-cyclodextrin Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 128446-34-4 |
| Product name | (2-Hydroxypropyl)-γ-cyclodextrin |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeFood GradeCosmetic Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (2-Hydroxypropyl)-γ-cyclodextrin
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (2-Hydroxypropyl)-γ-cyclodextrin Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (2-Hydroxypropyl)-γ-cyclodextrin
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Solubilizer and stabilizer for active pharmaceutical ingredients (APIs), enhancing aqueous solubility and bioavailability of poorly water-soluble drugs (e.g., itraconazole, paclitaxel) | Used as an excipient in formulations to form host–guest inclusion complexes via cyclodextrin complexation; applied in the development of oral solid dosage forms, injectables, and ophthalmic preparations |
| Food | Food additive for flavor encapsulation and controlled release, antioxidant carrier, and bitterness masking agent | Microencapsulation process: hydrophobic compounds (e.g., flavors, vitamins, or functional ingredients) are encapsulated within the cyclodextrin cavity to improve stability and sensory properties |
| Cosmetics | Stabilizer and skin penetration enhancer for active ingredients (e.g., retinol, vitamin E) | Used as a carrier in emulsions and serums; inclusion complexes are prepared via co-solvent or freeze-drying methods to enhance photostability and dermal permeation of actives |
| Agriculture | Adjuvant for agrochemicals, improving aqueous dispersibility and environmental stability of insecticides/fungicides | Inclusion complexation with agrochemical actives (e.g., abamectin, azoxystrobin) via ultrasonication or grinding to formulate water-based products and reduce organic solvent usage |
Manufacturing Quality Control of (2-Hydroxypropyl)-γ-cyclodextrin
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe sample color and physical state (typically white to off-white amorphous powder), and check for foreign particles. |
| Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare characteristic infrared absorption peaks (e.g., hydroxyl, ether bonds) with reference spectra to confirm structural features. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze chemical shifts and integral ratios of hydrogen atoms to verify the degree of hydroxypropyl substitution and the parent cyclodextrin structure. | |
| Solution Clarity and Color | Visual Color Comparison / Spectrophotometry | Prepare a solution at specified concentration, observe clarity, compare with standard color solutions, or measure absorbance at specific wavelengths. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Drying Method | Dry the sample at a specified temperature (e.g., 105°C) to constant weight; calculate percentage weight loss to determine moisture and volatile content. |
| Sulfated Ash (Residue on Ignition) | High-Temperature Incineration | Ignite the sample at high temperature (e.g., 600–800°C), then weigh the residual inorganic material to assess inorganic impurity levels. |
| pH Value | pH Meter Method | Prepare an aqueous solution of defined concentration (e.g., 5%), and measure acidity/alkalinity using a calibrated pH meter. |
| Degree of Substitution (DS) | ¹H NMR Method | Calculate average degree of substitution by comparing integral ratios of methyl proton signals from hydroxypropyl groups to protons from glucosyl units in the NMR spectrum. |
| Titration Method (Indirect) | Estimate hydroxypropyl content via derivatization (e.g., acetylation) followed by saponification titration (less common, lower accuracy). | |
| Related Substances / Impurities | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase or hydrophilic interaction chromatography to separate and detect unreacted starting materials (e.g., γ-cyclodextrin), by-products, and degradation products. |
| Assay | HPLC-ELSD or HPLC-RI | Quantify main component using Evaporative Light Scattering Detector (ELSD) or Refractive Index Detector (RI), with external standard method for calculation. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest sample and measure total content of heavy metal elements such as lead, arsenic, mercury, and cadmium; comply with pharmacopoeial limits. |
| Microbial Limits | Microbiological Culture Method | Perform tests for aerobic bacteria, mold/yeast counts, and specified microorganisms according to requirements of Chinese Pharmacopoeia or USP. |
| Residual Solvents | Gas Chromatography (GC) | Headspace GC to detect residual organic solvents from synthesis (e.g., propylene oxide, isopropanol). |
| Molecular Weight Distribution | Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) | Evaluate polymerization distribution and presence of high-molecular-weight impurities to ensure product uniformity. |
Technical Specifications of (2-Hydroxypropyl)-γ-cyclodextrin
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +140 to +150 (c=1, H2O) |
| Residue on Ignition | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (2-Hydroxypropyl)-γ-cyclodextrin
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (2-Hydroxypropyl)-γ-cyclodextrin
Safety Information of (2-Hydroxypropyl)-γ-cyclodextrin
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (2-Hydroxypropyl)-γ-cyclodextrin
Industrial (2-Hydroxypropyl)-γ-cyclodextrin Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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