2-Hydroxypropyl-β-cyclodextrin Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 128446-35-5 |
| Product name | 2-Hydroxypropyl-β-cyclodextrin |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Hydroxypropyl-β-cyclodextrin
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Hydroxypropyl-β-cyclodextrin Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Hydroxypropyl-β-cyclodextrin
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Solubilization and co-solubilization of poorly water-soluble drugs | Formation of inclusion complexes to enhance drug bioavailability |
| Pharmaceutical Industry | Improvement of drug stability | Prevention of drug oxidation, hydrolysis, or photolysis; masking of undesirable odors |
| Pharmaceutical Industry | Reduction of drug toxicity and side effects | Reduction of drug-induced irritation to tissues or mucosal membranes |
| Pharmaceutical Industry | Sustained- and controlled-release formulations | Modulation of drug release rate |
| Food Industry | Stabilizer and emulsifier | Encapsulation of volatile flavor compounds or oils to prevent volatilization or oxidation |
| Food Industry | Masking of undesirable odors | Reduction of bitterness or off-flavors |
| Cosmetics Industry | Stabilization of active ingredients | Reduction of degradation of light- or heat-sensitive components |
| Cosmetics Industry | Improvement of skin feel and reduction of irritation | Reduction of skin irritation caused by surfactants or other irritating ingredients |
| Agriculture/Pesticides | Enhancement of pesticide stability | Improvement of stability and dispersibility of liquid pesticides |
Manufacturing Quality Control of 2-Hydroxypropyl-β-cyclodextrin
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | By measuring the infrared absorption spectrum of the sample and comparing it with the standard spectrum, the molecular structure characteristics are confirmed. |
| Nuclear Magnetic Resonance (NMR) | Using ¹H-NMR or ¹³C-NMR to analyze the chemical environment of hydrogen or carbon in the molecule, confirming the presence and degree of substitution of hydroxypropyl groups. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Reverse-phase HPLC is used to quantitatively determine the content of the main component by retention time and peak area, often combined with evaporative light scattering detector (ELSD) or charged aerosol detector (CAD). |
| Differential Scanning Calorimetry (DSC) combined with standard curve | Establishing a standard curve using thermodynamic behavior to indirectly determine the content (rarely used, more for auxiliary analysis). | |
| Drying Loss | Thermogravimetric Analysis (TGA) or oven drying method | Drying the sample to constant weight at a specified temperature (e.g., 105°C), calculating the percentage of weight loss to reflect moisture and volatile impurity content. |
| Moisture | Karl Fischer Titration | A specific method for determining water content, suitable for trace moisture detection, with accurate and reliable results. |
| Substitution Degree (DS) | NMR (¹H-NMR) | Calculating the average substitution degree by comparing the integral areas of the cyclodextrin framework protons and the hydroxypropyl methyl protons. |
| Elemental Analysis | Determining the content of C, H, O elements in the sample, and calculating the substitution degree based on theoretical composition (lower accuracy, used as an auxiliary method). | |
| Heavy Metals | Atomic Absorption Spectrometry (AAS) or ICP-MS | Digesting the sample and then determining the content of heavy metal elements such as lead, cadmium, mercury, and arsenic, meeting the pharmacopoeia limits. |
| Clarity and Color | Visual Colorimetry | Preparing a solution of a certain concentration and comparing it with a standard color solution to evaluate the clarity and color of the solution. |
| pH Value | pH Meter Method | Dissolving the sample in water and directly measuring the pH value of the solution using a calibrated pH meter, typically controlled within the range of 5.0–8.0. |
| Residual Solvents | Gas Chromatography (GC) | Detecting residual organic solvents (such as epichlorohydrin, isopropanol, etc.) during production using headspace-GC method, meeting ICH limits. |
| Microbial Limit | Microbial Limit Test Method | Performing tests for total aerobic bacteria count, mold and yeast count, and control bacteria (such as Escherichia coli) according to the pharmacopoeia requirements to ensure sterility safety. |
| Bacterial Endotoxins | Limulus Amebocyte Lysate (LAL) Method | Using gel clot method or kinetic turbidimetric method to detect bacterial endotoxin content, suitable for injectable products, typically with a limit of <0.5 EU/mg. |
| Particle Size Distribution | Laser Diffraction Analysis | Determining particle size and its distribution through laser scattering principles, suitable for quality control of solid powders. |
Technical Specifications of 2-Hydroxypropyl-β-cyclodextrin
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.5% |
| Optical Rotation | +125° to +145° (c=1, H2O) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Hydroxypropyl-β-cyclodextrin
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Hydroxypropyl-β-cyclodextrin
Packaging of 2-Hydroxypropyl-β-cyclodextrin
Industrial 2-Hydroxypropyl-β-cyclodextrin Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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