Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 128625-52-5 |
| Product name | Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 128625-52-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 128625-52-5 Supplier from China
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Industrial Applications of 128625-52-5
| Industry | Application | Process |
|---|---|---|
| Chemical Synthesis | Coupling reagent in peptide synthesis | Activates carboxyl groups to facilitate peptide bond formation between amino acids, commonly used in solid-phase or solution-phase peptide synthesis |
| Pharmaceutical Industry | Coupling reactions for drug molecule intermediates | Acts as an efficient condensing agent for synthesizing drug active pharmaceutical ingredients containing amide bonds, enhancing reaction selectivity and yield |
| Biochemical Research | Peptide and protein modification | Enables selective coupling of specific amino and carboxyl groups under mild conditions, supporting protein engineering and functionalization studies |
Manufacturing Quality Control of 128625-52-5
| Test Item | Common Testing Method | Method Summary |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with gradient elution of acetonitrile-water (containing 0.1% trifluoroacetic acid) as mobile phase. UV detection is typically performed at 210–254 nm. The content of the main component is calculated using external standard or area normalization methods to assess total impurities, meeting pharmacopoeial or enterprise standards (e.g., ≥98.0%). |
| Moisture Content | Karl Fischer Titration | Determines trace moisture in samples based on the quantitative reaction between iodine and water, using coulometric or volumetric titration. Suitable for controlling hygroscopic impurities in organic salts; typically requires moisture ≤0.5% (w/w). |
| Residual Solvents | Gas Chromatography (GC) | Employs capillary columns such as DB-624 or HP-INNOWAX with headspace injection to detect residual solvents commonly used in synthesis (e.g., acetonitrile, dichloromethane, acetone). Complies with ICH Q3C guidelines, ensuring solvent levels are within permissible limits (e.g., acetonitrile ≤410 ppm). |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion, determines concentrations of heavy metal elements such as lead, cadmium, mercury, and arsenic. Meets ICH Q3D or pharmacopoeial requirements (e.g., total heavy metals ≤10 ppm). |
| Hexafluorophosphate Ion (PF₆⁻) Content | Ion Chromatography (IC) or Fluoride Ion-Selective Electrode Method | Separates PF₆⁻ using an anion-exchange column with conductivity detection; alternatively, uses a fluoride ion-selective electrode with Total Ionic Strength Adjustment Buffer (TISAB). Ensures the anion composition meets stoichiometric expectations (theoretical content approximately 42.5%). |
| Appearance and Color | Visual Inspection + Color Measurement | Observes the solid powder color (should be white to off-white); colorimeter or colorimetric methods (e.g., APHA color scale) may be used if necessary to evaluate yellowing caused by degradation or impurities. |
| Melting Point / Thermal Stability | Differential Scanning Calorimetry (DSC) | Determines melting endothermic peak (PyBOP around 105–115°C), assessing purity and crystalline form consistency. Abnormal melting ranges or exothermic peaks may indicate decomposition or presence of impurities. |
| pH Value (Aqueous Solution) | pH Meter Measurement | Sample is prepared as a 1% aqueous solution and pH is measured (typically neutral to slightly acidic, pH 5.5–7.5), reflecting residual hydrolysis products such as benzotriazole. |
| Microbial Limits | Plate Count Method / Rapid Microbial Detection Systems | For raw materials intended for sterile formulations, tests total aerobic microbial count, molds and yeasts, and specified microorganisms (e.g., Escherichia coli). Complies with microbial limits for non-sterile pharmaceuticals (e.g., USP <61>). |
| Infrared Spectroscopic Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Records the infrared spectrum of the sample and compares characteristic absorption peaks (e.g., P=O, P–O–N, benzotriazole ring C=N, PF₆⁻ features) with reference spectra for structural confirmation. |
| Nuclear Magnetic Resonance (¹H NMR / ¹³C NMR) | Nuclear Magnetic Resonance Spectroscopy | Measurement in DMSO-d₆ or CDCl₃; confirms structure through characteristic proton signals (e.g., benzotriazole H-4/H-5/H-6/H-7, pyrrolidine CH₂ groups; PF₆⁻ gives no signal), used for structural verification of high-purity samples. |
Technical Specifications of 128625-52-5
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow powder or crystals |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Industrial 128625-52-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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